| pubmed-article:10477719 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10477719 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10477719 | lifeskim:mentions | umls-concept:C0021757 | lld:lifeskim |
| pubmed-article:10477719 | lifeskim:mentions | umls-concept:C1268930 | lld:lifeskim |
| pubmed-article:10477719 | lifeskim:mentions | umls-concept:C1518071 | lld:lifeskim |
| pubmed-article:10477719 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:10477719 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10477719 | pubmed:dateCreated | 1999-10-12 | lld:pubmed |
| pubmed-article:10477719 | pubmed:abstractText | Expansion of early lymphoid progenitors requires interleukin-7 (IL-7), which functions through gamma(c)-mediated receptor activation of Jak3. Jak3 deficiency is a cause of severe combined immunodeficiency (SCID) in humans and mice. IL-3 activates many of the same signaling pathways as IL-7, such as Stat5, but achieves this effect through the activation of Jak2 rather than Jak3. We hypothesized that expansion of an IL-7-responsive precursor population through a Jak3-independent pathway using IL-3 may stimulate early lymphoid progenitors and restore lymphopoiesis in Jak3(-/-) mice. Newborn Jak3(-/-) mice that were injected with IL-3 demonstrated thymic enlargement, a 2- to 20-fold increase in thymocyte numbers, and up to a 10-fold expansion in the number of CD4(+), CD8(+), and B220(+)/IgM(+) splenic lymphocytes, consistent with an effect upon an early lymphoid progenitor population. In contrast to control mice, IL-3-treated Jak3(-/-) mice challenged with the allogeneic major histocompatibility complex (MHC) class I-bearing tumor P815 developed a specific CD8-dependent cytotoxic T lymphocyte (CTL) response. IL-3-treated mice also mounted influenza-specific CTL responses and survival was prolonged. The beneficial effects of IL-3 are proposed to be produced by stimulation of a lymphoid precursor population of IL-7Ralpha(+)/IL-3Ralpha(+) cells that we identified in wild-type bone marrow. In vitro, we show that an early IL-7R(+) lymphoid progenitor population expresses IL-3R and proliferates in response to IL-3 and that IL-3 activates Stat5 comparably to IL-7. Clinically, IL-3 may therefore be useful treatment for X-linked and Jak3-deficient SCID patients who lack bone marrow donors. | lld:pubmed |
| pubmed-article:10477719 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10477719 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10477719 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10477719 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10477719 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10477719 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10477719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10477719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10477719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10477719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10477719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10477719 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10477719 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10477719 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:10477719 | pubmed:author | pubmed-author:IhleJ NJN | lld:pubmed |
| pubmed-article:10477719 | pubmed:author | pubmed-author:DohertyP CPC | lld:pubmed |
| pubmed-article:10477719 | pubmed:author | pubmed-author:BrooksJJ | lld:pubmed |
| pubmed-article:10477719 | pubmed:author | pubmed-author:BrownM PMP | lld:pubmed |
| pubmed-article:10477719 | pubmed:author | pubmed-author:NosakaTT | lld:pubmed |
| pubmed-article:10477719 | pubmed:author | pubmed-author:BrennerM KMK | lld:pubmed |
| pubmed-article:10477719 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:10477719 | pubmed:author | pubmed-author:TrippR ARA | lld:pubmed |
| pubmed-article:10477719 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10477719 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10477719 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:10477719 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10477719 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10477719 | pubmed:pagination | 1906-14 | lld:pubmed |
| pubmed-article:10477719 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10477719 | pubmed:meshHeading | pubmed-meshheading:10477719... | lld:pubmed |
| pubmed-article:10477719 | pubmed:meshHeading | pubmed-meshheading:10477719... | lld:pubmed |
| pubmed-article:10477719 | pubmed:meshHeading | pubmed-meshheading:10477719... | lld:pubmed |
| pubmed-article:10477719 | pubmed:meshHeading | pubmed-meshheading:10477719... | lld:pubmed |
| pubmed-article:10477719 | pubmed:meshHeading | pubmed-meshheading:10477719... | lld:pubmed |
| pubmed-article:10477719 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10477719 | pubmed:articleTitle | Reconstitution of early lymphoid proliferation and immune function in Jak3-deficient mice by interleukin-3. | lld:pubmed |
| pubmed-article:10477719 | pubmed:affiliation | Howard Hughes Medical Institute, Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN, USA. | lld:pubmed |
| pubmed-article:10477719 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10477719 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10477719 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16453 | entrezgene:pubmed | pubmed-article:10477719 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10477719 | lld:pubmed |
