| pubmed-article:10474161 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10474161 | lifeskim:mentions | umls-concept:C0008046 | lld:lifeskim |
| pubmed-article:10474161 | lifeskim:mentions | umls-concept:C0015385 | lld:lifeskim |
| pubmed-article:10474161 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:10474161 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10474161 | pubmed:dateCreated | 1999-10-18 | lld:pubmed |
| pubmed-article:10474161 | pubmed:abstractText | Dlx-5 is a vertebrate homolog of the Drosophila Distal-less gene, one of the first genetic signals for limb formation in the fly. In the present study we have explored the possible role of Dlx-5 in limb initiation in the chick embryo. At stage 14 which is well before the initial formation of limb buds Dlx-5 is highly and specifically expressed in the ectoderm of the presumptive wing and leg forming regions of the lateral plate, but not in the intervening non-limb forming prospective flank. Thus, Dlx-5 expression distinguishes the limb-forming territories prior to limb budding, and is one of the first molecular markers of vertebrate limb initiation. Furthermore, Dlx-5 expression is induced in the non-limb-forming flank within 12 hours after implantation of an FGF2-soaked bead, a procedure that results in the induction of an ectopic limb. The rapid induction of Dlx-5 expression in response to a signal which ultimately leads to supernumerary limb formation is consistent with a role for Dlx-5 in limb initiation. We have also examined the expression of Dlx-5 in the limb buds of amelic limbless mutant chick embryos, which undergo normal limb formation but do not form an AER and thus fail to undergo further outgrowth. Dlx-5 is transiently expressed by the ectoderm of emergent limbless limb buds, consistent with a role for Dlx-5 in limb initiation. Together, our results suggest that Dlx-5 may be involved in the specification of the limb territories of the lateral plate, and in the initial formation of the limb bud from these regions. Dev Dyn 1999;216:10-15. | lld:pubmed |
| pubmed-article:10474161 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10474161 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10474161 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10474161 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10474161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10474161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10474161 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10474161 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10474161 | pubmed:issn | 1058-8388 | lld:pubmed |
| pubmed-article:10474161 | pubmed:author | pubmed-author:KosherR ARA | lld:pubmed |
| pubmed-article:10474161 | pubmed:author | pubmed-author:FerrariDD | lld:pubmed |
| pubmed-article:10474161 | pubmed:author | pubmed-author:HarringtonAA | lld:pubmed |
| pubmed-article:10474161 | pubmed:author | pubmed-author:DealyC NCN | lld:pubmed |
| pubmed-article:10474161 | pubmed:copyrightInfo | Copyright 1999 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:10474161 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10474161 | pubmed:volume | 216 | lld:pubmed |
| pubmed-article:10474161 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10474161 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10474161 | pubmed:pagination | 10-5 | lld:pubmed |
| pubmed-article:10474161 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10474161 | pubmed:meshHeading | pubmed-meshheading:10474161... | lld:pubmed |
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| pubmed-article:10474161 | pubmed:meshHeading | pubmed-meshheading:10474161... | lld:pubmed |
| pubmed-article:10474161 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10474161 | pubmed:articleTitle | Dlx-5 in limb initiation in the chick embryo. | lld:pubmed |
| pubmed-article:10474161 | pubmed:affiliation | Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA. | lld:pubmed |
| pubmed-article:10474161 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10474161 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10474161 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10474161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10474161 | lld:pubmed |
