| pubmed-article:10471007 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10471007 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:10471007 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10471007 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:10471007 | lifeskim:mentions | umls-concept:C0225957 | lld:lifeskim |
| pubmed-article:10471007 | lifeskim:mentions | umls-concept:C0037663 | lld:lifeskim |
| pubmed-article:10471007 | lifeskim:mentions | umls-concept:C0042402 | lld:lifeskim |
| pubmed-article:10471007 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:10471007 | lifeskim:mentions | umls-concept:C0252545 | lld:lifeskim |
| pubmed-article:10471007 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10471007 | pubmed:dateCreated | 1999-10-22 | lld:pubmed |
| pubmed-article:10471007 | pubmed:abstractText | The endothelial vasodilation mechanism(s) has been investigated in aortic rings of hypophysectomized male rats as well as hypophysectomized rats treated for 7 days with growth hormone (GH, 400 microg/kg, s.c.) or hexarelin (80 microg/kg, s.c.). Tissue preparations from intact animals were taken as controls. The results obtained indicate that the release of 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha) from aortic rings of hypophysectomized rats was markedly reduced (51%; p<0.01) as compared with that of control preparations; the peak response to cumulative concentration of endothelin-1 (ET-1, from 10(-11) to 10(-5) M) was increased 2.4-fold (p<0.01) versus controls; the relaxant activity of acetylcholine (ACh, from 10(-10) to 10(-4) M) in norepinephrine-precontracted aortic rings was reduced by 39.5+/-4.4%. Pretreatment of hypophysectomized rats with GH or hexarelin markedly antagonized the hyperresponsiveness of the aortic tissue to ET-1 and allowed a consistent recovery of both the relaxant activity of ACh and the generation of 6-keto-PGF1alpha. Collectively these findings support the concept that dysfunction of vascular endothelial cells may be induced by a defective GH function. Because a replacement regimen of GH restored the somatotropic function and increased plasma insulin-like growth factor-I (IGF-I) concentrations in the hypophysectomized rats, it is suggested that IGF-I may have protected the vascular endothelium acting as a biologic mediator of GH action. In contrast to GH, hexarelin replacement neither increased body weight nor affected the plasma concentrations of IGF-I, indicating that its beneficial action on vascular endothelium was divorced from that on somatotropic function and was likely due to activation of specific endothelial receptors. | lld:pubmed |
| pubmed-article:10471007 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10471007 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471007 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10471007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10471007 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10471007 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10471007 | pubmed:issn | 0160-2446 | lld:pubmed |
| pubmed-article:10471007 | pubmed:author | pubmed-author:NilssonMM | lld:pubmed |
| pubmed-article:10471007 | pubmed:author | pubmed-author:LocatelliVV | lld:pubmed |
| pubmed-article:10471007 | pubmed:author | pubmed-author:MüllerE EEE | lld:pubmed |
| pubmed-article:10471007 | pubmed:author | pubmed-author:BertiFF | lld:pubmed |
| pubmed-article:10471007 | pubmed:author | pubmed-author:RossoniGG | lld:pubmed |
| pubmed-article:10471007 | pubmed:author | pubmed-author:SchweigerFF | lld:pubmed |
| pubmed-article:10471007 | pubmed:author | pubmed-author:TorselloAA | lld:pubmed |
| pubmed-article:10471007 | pubmed:author | pubmed-author:De Gennaro... | lld:pubmed |
| pubmed-article:10471007 | pubmed:author | pubmed-author:BoghenMM | lld:pubmed |
| pubmed-article:10471007 | pubmed:author | pubmed-author:BernareggiMM | lld:pubmed |
| pubmed-article:10471007 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10471007 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:10471007 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10471007 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10471007 | pubmed:pagination | 454-60 | lld:pubmed |
| pubmed-article:10471007 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10471007 | pubmed:meshHeading | pubmed-meshheading:10471007... | lld:pubmed |
| pubmed-article:10471007 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10471007 | pubmed:articleTitle | Growth hormone and hexarelin prevent endothelial vasodilator dysfunction in aortic rings of the hypophysectomized rat. | lld:pubmed |
| pubmed-article:10471007 | pubmed:affiliation | Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy. giuseppe.rossoni@unimi.it | lld:pubmed |
| pubmed-article:10471007 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10471007 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10471007 | lld:pubmed |
