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pubmed-article:10470190pubmed:abstractTextMeasurement of CA125 is well established in the diagnosis and follow-up of ovarian cancer. CA125 determination is usually performed with the monoclonal antibodies OC125 and M11. For the IMMULITE OM-MA chemoluminsence assay (DPC Biermann, Bad Nauheim, Germany) the monoclonal antibody OV185 is used. We analysed CA125 serum concentrations of patients with benign and malignant ovarian tumors with the IMMULITE OM-MA assay by defining a cut-off at 90% specificity level. Sera of 130 patients with benign and 119 patients with malignant ovarian tumors at different FIGO stages were analysed. By calculating a cut-off of 46 U/ml, in 87 ovarian cancer patients, elevated CA125 concentrations were detected (78% sensitivity). There were no significant differences between CA125 concentrations of tumors of different histological type. The measurement of CA125 by IMMULITE OM-MA is a simple and sensitive procedure.lld:pubmed
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pubmed-article:10470190pubmed:authorpubmed-author:RiegerMMlld:pubmed
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pubmed-article:10470190pubmed:pagination2535-6lld:pubmed
pubmed-article:10470190pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:10470190pubmed:articleTitleIMMULITE OM-MA assay: a useful diagnostic tool in patients with benign and malignant ovarian tumors.lld:pubmed
pubmed-article:10470190pubmed:affiliationDepartment of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Germany. gerhard.gebauer@rzmail.uni-erlangen.delld:pubmed
pubmed-article:10470190pubmed:publicationTypeJournal Articlelld:pubmed