Linked Life Data

10469173

Source:http://linkedlifedata.com/resource/pubmed/id/10469173

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pubmed-article:10469173pubmed:abstractTextUpon Fas stimulation, procaspase-8 is recruited to the death-inducing signalling complex where autoactivation of caspase-8 occurs. Active caspase-8 can directly activate downstream caspases (e.g. caspase-3, 6, and 7) for the execution of apoptosis (mitochondria-independent pathway), while caspase-8 can also lead to executioner caspase activation through mitochondrial damage (mitochondria-dependent pathway). Caspase activation results in the dismantling of intracellular structure through specific proteolysis.lld:pubmed
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pubmed-article:10469173pubmed:articleTitleChanges in nuclear morphology during apoptosis correlate with vimentin cleavage by different caspases located either upstream or downstream of Bcl-2 action.lld:pubmed
pubmed-article:10469173pubmed:affiliationBiodesign Research Group, RIKEN (the Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. morishim@postman.riken.go.jplld:pubmed
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