| pubmed-article:10459019 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10459019 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:10459019 | lifeskim:mentions | umls-concept:C0872097 | lld:lifeskim |
| pubmed-article:10459019 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10459019 | lifeskim:mentions | umls-concept:C1155873 | lld:lifeskim |
| pubmed-article:10459019 | lifeskim:mentions | umls-concept:C0009835 | lld:lifeskim |
| pubmed-article:10459019 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10459019 | lifeskim:mentions | umls-concept:C1515979 | lld:lifeskim |
| pubmed-article:10459019 | lifeskim:mentions | umls-concept:C0205228 | lld:lifeskim |
| pubmed-article:10459019 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10459019 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10459019 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10459019 | pubmed:dateCreated | 1999-9-23 | lld:pubmed |
| pubmed-article:10459019 | pubmed:abstractText | beta-Catenin is an important regulator of cell-cell adhesion and embryonic development that associates with and regulates the function of the LEF/TCF family of transcription factors. Mutations of beta-catenin and the tumor suppressor gene, adenomatous polyposis coli, occur in human cancers, but it is not known if, and by what mechanism, increased beta-catenin causes cellular transformation. This study demonstrates that modest overexpression of beta-catenin in a normal epithelial cell results in cellular transformation. These cells form colonies in soft agar, survive in suspension, and continue to proliferate at high cell density and following gamma-irradiation. Endogenous cytoplasmic beta-catenin levels and signaling activity were also found to oscillate during the cell cycle. Taken together, these data demonstrate that beta-catenin functions as an oncogene by promoting the G(1) to S phase transition and protecting cells from suspension-induced apoptosis (anoikis). | lld:pubmed |
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| pubmed-article:10459019 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10459019 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10459019 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10459019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10459019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10459019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10459019 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10459019 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10459019 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:10459019 | pubmed:author | pubmed-author:ByersS WSW | lld:pubmed |
| pubmed-article:10459019 | pubmed:author | pubmed-author:OrfordKK | lld:pubmed |
| pubmed-article:10459019 | pubmed:author | pubmed-author:OrfordC CCC | lld:pubmed |
| pubmed-article:10459019 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10459019 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:10459019 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:10459019 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10459019 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10459019 | pubmed:pagination | 855-68 | lld:pubmed |
| pubmed-article:10459019 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10459019 | pubmed:meshHeading | pubmed-meshheading:10459019... | lld:pubmed |
| pubmed-article:10459019 | pubmed:meshHeading | pubmed-meshheading:10459019... | lld:pubmed |
