| pubmed-article:10457211 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10457211 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10457211 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:10457211 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:10457211 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10457211 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10457211 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10457211 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10457211 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10457211 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10457211 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:10457211 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10457211 | pubmed:dateCreated | 1999-10-4 | lld:pubmed |
| pubmed-article:10457211 | pubmed:abstractText | An in vivo model of pulmonary granuloma formation around embolized schistosome eggs was investigated as an environment in which to analyse a role for interleukin-12 (IL-12) in the differentiation of T-helper 1 (Th1) and Th2 subsets. Specifically, mice deficient for the interferon-gamma receptor (IFN-gammaR-/-) were used to determine the role for IL-12 in the absence of IFN-gamma-mediated signalling. We show that recombinant IL-12 administered to IFN-gammaR-/- mice caused the up-regulation of mRNA for IFN-gamma in lung tissue, and the secretion of abundant IFN-gamma by in vitro-cultured lymph node cells in response to egg antigens. This indicates that IL-12 can act independently of IFN-gamma to induce the development of Th1 cells. Administration of rIL-12 to wild-type mice markedly reduced the secretion of Th2-associated cytokines, IL-4 and IL-5. However, these cytokines were not dramatically reduced in IFN-gammaR-/- mice treated with IL-12. We conclude that inhibition of these cytokines by IL-12 is primarily dependent upon effective IFN-gamma signalling, although abrogation of T-cell derived IL-10 appeared to be dependent upon IL-12. We also show that increases in mRNA for the beta2 subunit of the IL-12 receptor and the p40 subunit of IL-12 after rIL-12 treatment were lower in IFN-gammaR-/- mice, compared to wild-type mice, indicating that their expression was primarily dependent upon IFN-gamma with only a minor role for IL-12. | lld:pubmed |
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| pubmed-article:10457211 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10457211 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10457211 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10457211 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10457211 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:10457211 | pubmed:author | pubmed-author:SherAA | lld:pubmed |
| pubmed-article:10457211 | pubmed:author | pubmed-author:WilsonR ARA | lld:pubmed |
| pubmed-article:10457211 | pubmed:author | pubmed-author:CheeverA WAW | lld:pubmed |
| pubmed-article:10457211 | pubmed:author | pubmed-author:WynnT ATA | lld:pubmed |
| pubmed-article:10457211 | pubmed:author | pubmed-author:CoulsonP SPS | lld:pubmed |
| pubmed-article:10457211 | pubmed:author | pubmed-author:MountfordA... | lld:pubmed |
| pubmed-article:10457211 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10457211 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:10457211 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10457211 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10457211 | pubmed:pagination | 588-94 | lld:pubmed |
| pubmed-article:10457211 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10457211 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10457211 | pubmed:articleTitle | Interleukin-12 can directly induce T-helper 1 responses in interferon-gamma (IFN-gamma) receptor-deficient mice, but requires IFN-gamma signalling to downregulate T-helper 2 responses. | lld:pubmed |
| pubmed-article:10457211 | pubmed:affiliation | Department of Biology, The University of York, York, UK. | lld:pubmed |
| pubmed-article:10457211 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10457211 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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