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pubmed-article:10455888pubmed:abstractTextThe prognosis for gastric cancer remains dismal; novel agents that target specific molecular pathways are needed as adjuvant therapy. Camptothecin (CPT), on inhibitor of topoisomerase I, is effective in the treatment of certain solid tumors; its effects on gastric cancer are largely undefined. The purpose of this study was to (1) characterize the effects of CPT on the growth of a human gastric cancer and (2) assess potential cellular mechanisms responsible for CPT-mediated growth inhibition.lld:pubmed
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pubmed-article:10455888pubmed:articleTitleInhibition of gastric cancer by camptothecin involves apoptosis and multiple cellular pathways.lld:pubmed
pubmed-article:10455888pubmed:affiliationDepartment of Surgery, University of Texas Medical Branch, Galveston 77555-0533, USA.lld:pubmed
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pubmed-article:10455888pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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