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pubmed-article:10454720pubmed:abstractTextWe have previously demonstrated that patients with mitochondrial myopathies can benefit from short-term aerobic exercise training. In this study, we compared the responses to short-term aerobic training of patients with mitochondrial myopathies, patients with nonmetabolic myopathies, and sedentary normal subjects. Training consisted of 8 weeks of treadmill exercise at 70% to 85% of estimated maximum heart rate reserve. All groups showed significant improvements in estimated aerobic capacity as well as heart rate and blood lactate at submaximal exercise intensities. The increase in estimated aerobic capacity was greater in the mitochondrial myopathy patients than in the other two groups. Phosphorus magnetic resonance spectroscopy demonstrated increased oxidative capacity of muscle in patients with mitochondrial myopathies in response to this training but not in patients with other, nonmetabolic myopathies or sedentary control subjects. A self-assessed measurement of functional status (SF-36) suggested improved quality of life associated with the training. This study demonstrates that short-term aerobic training at low intensity can benefit patients with nonmetabolic myopathies but to a lesser extent than patients with mitochondrial myopathies.lld:pubmed
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pubmed-article:10454720pubmed:copyrightInfoCopyright 1999 John Wiley & Sons, Inc.lld:pubmed
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pubmed-article:10454720pubmed:pagination1239-43lld:pubmed
pubmed-article:10454720pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10454720pubmed:articleTitleShort-term aerobic training response in chronic myopathies.lld:pubmed
pubmed-article:10454720pubmed:affiliationDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Canada.lld:pubmed
pubmed-article:10454720pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10454720pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:10454720pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed