| pubmed-article:10454574 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10454574 | lifeskim:mentions | umls-concept:C0949879 | lld:lifeskim |
| pubmed-article:10454574 | lifeskim:mentions | umls-concept:C0920283 | lld:lifeskim |
| pubmed-article:10454574 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10454574 | lifeskim:mentions | umls-concept:C1421544 | lld:lifeskim |
| pubmed-article:10454574 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10454574 | pubmed:dateCreated | 1999-9-10 | lld:pubmed |
| pubmed-article:10454574 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10454574 | pubmed:abstractText | CRM1 is an export receptor mediating rapid nuclear exit of proteins and RNAs to the cytoplasm. CRM1 export cargoes include proteins with a leucine-rich nuclear export signal (NES) that bind directly to CRM1 in a trimeric complex with RanGTP. Using a quantitative CRM1-NES cargo binding assay, significant differences in affinity for CRM1 among natural NESs are demonstrated, suggesting that the steady-state nucleocytoplasmic distribution of shuttling proteins could be determined by the relative strengths of their NESs. We also show that a trimeric CRM1-NES-RanGTP complex is disassembled by RanBP1 in the presence of RanGAP, even though RanBP1 itself contains a leucine-rich NES. Selection of CRM1-binding proteins from Xenopus egg extract leads to the identification of an NES-containing DEAD-box helicase, An3, that continuously shuttles between the nucleus and the cytoplasm. In addition, we identify the Xenopus homologue of the nucleoporin CAN/Nup214 as a RanGTP- and NES cargo-specific binding site for CRM1, suggesting that this nucleoporin plays a role in export complex disassembly and/or CRM1 recycling. | lld:pubmed |
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| pubmed-article:10454574 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10454574 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10454574 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10454574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10454574 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10454574 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10454574 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:10454574 | pubmed:author | pubmed-author:OhnoMM | lld:pubmed |
