| pubmed-article:10454355 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10454355 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10454355 | lifeskim:mentions | umls-concept:C0023185 | lld:lifeskim |
| pubmed-article:10454355 | lifeskim:mentions | umls-concept:C1704689 | lld:lifeskim |
| pubmed-article:10454355 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:10454355 | lifeskim:mentions | umls-concept:C0040135 | lld:lifeskim |
| pubmed-article:10454355 | lifeskim:mentions | umls-concept:C0424295 | lld:lifeskim |
| pubmed-article:10454355 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:10454355 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:10454355 | pubmed:issue | 4-5 | lld:pubmed |
| pubmed-article:10454355 | pubmed:dateCreated | 1999-9-8 | lld:pubmed |
| pubmed-article:10454355 | pubmed:abstractText | Resistance to thyroid hormone (RTH) is a human syndrome mapped to the thyroid receptor beta (TRbeta) gene on chromosome 3, representing a mutation of the ligand-binding domain of the TRbeta gene. The syndrome is characterized by reduced tissue responsiveness to thyroid hormone and elevated serum levels of thyroid hormones. A common behavioral phenotype associated with RTH is attention deficit hyperactivity disorder (ADHD). To test the hypothesis that RTH produces attention deficits and/or hyperactivity, transgenic mice expressing a mutant TRbeta gene were generated. The present experiment tested RTH transgenic mice from the PV kindred on behavioral tasks relevant to the primary features of ADHD: hyperactivity, sustained attention (vigilance), learning, and impulsivity. Male transgenic mice showed elevated locomotor activity in an open field compared to male wild-type littermate controls. Both male and female transgenic mice exhibited impaired learning of an autoshaping task, compared to wild-type controls. On a vigilance task in an operant chamber, there were no differences between transgenics and controls on the proportion of hits, response latency, or duration of stimulus tolerated. On an operant go/no-go task measuring sustained attention and impulsivity, there were no differences between controls and transgenics. These results indicate that transgenic mice bearing a mutant human TRbeta gene demonstrate several behavioral characteristics of ADHD and may serve a valuable heuristic role in elucidating possible candidate genes in converging pathways for other causes of ADHD. | lld:pubmed |
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| pubmed-article:10454355 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10454355 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10454355 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10454355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10454355 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10454355 | pubmed:issn | 1072-0502 | lld:pubmed |
| pubmed-article:10454355 | pubmed:author | pubmed-author:GoldsteinGG | lld:pubmed |
| pubmed-article:10454355 | pubmed:author | pubmed-author:ChengS YSY | lld:pubmed |
| pubmed-article:10454355 | pubmed:author | pubmed-author:CrawleyJ NJN | lld:pubmed |
| pubmed-article:10454355 | pubmed:author | pubmed-author:WeintraubBB | lld:pubmed |
| pubmed-article:10454355 | pubmed:author | pubmed-author:McDonaldM PMP | lld:pubmed |
| pubmed-article:10454355 | pubmed:author | pubmed-author:WongRR | lld:pubmed |
| pubmed-article:10454355 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10454355 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:10454355 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10454355 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10454355 | pubmed:pagination | 289-301 | lld:pubmed |
| pubmed-article:10454355 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
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