| pubmed-article:10454353 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10454353 | lifeskim:mentions | umls-concept:C0023185 | lld:lifeskim |
| pubmed-article:10454353 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10454353 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:10454353 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:10454353 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:10454353 | pubmed:issue | 4-5 | lld:pubmed |
| pubmed-article:10454353 | pubmed:dateCreated | 1999-9-8 | lld:pubmed |
| pubmed-article:10454353 | pubmed:abstractText | A-type K+ channels are known to regulate neuronal firing, but their role in repetitive firing and learning in mammals is not well characterized. To determine the contribution of the auxiliary K+ channel subunit Kvbeta1.1 to A-type K+ currents and to study the physiological role of A-type K+ channels in repetitive firing and learning, we deleted the Kvbeta1.1 gene in mice. The loss of Kvbeta1.1 resulted in a reduced K+ current inactivation in hippocampal CA1 pyramidal neurons. Furthermore, in the mutant neurons, frequency-dependent spike broadening and the slow afterhyperpolarization (sAHP) were reduced. This suggests that Kvbeta1.1-dependent A-type K+ channels contribute to frequency-dependent spike broadening and may regulate the sAHP by controlling Ca2+ influx during action potentials. The Kvbeta1.1-deficient mice showed normal synaptic plasticity but were impaired in the learning of a water maze test and in the social transmission of food preference task, indicating that the Kvbeta1.1 subunit contributes to certain types of learning and memory. | lld:pubmed |
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| pubmed-article:10454353 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10454353 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10454353 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10454353 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10454353 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10454353 | pubmed:issn | 1072-0502 | lld:pubmed |
| pubmed-article:10454353 | pubmed:author | pubmed-author:SilvaA JAJ | lld:pubmed |
| pubmed-article:10454353 | pubmed:author | pubmed-author:PongsOO | lld:pubmed |
| pubmed-article:10454353 | pubmed:author | pubmed-author:FedorovN BNB | lld:pubmed |
| pubmed-article:10454353 | pubmed:author | pubmed-author:ReuterDD | lld:pubmed |
| pubmed-article:10454353 | pubmed:author | pubmed-author:StoryJ BJB | lld:pubmed |
| pubmed-article:10454353 | pubmed:author | pubmed-author:GieseK PKP | lld:pubmed |
| pubmed-article:10454353 | pubmed:author | pubmed-author:ShawL JLJ | lld:pubmed |
| pubmed-article:10454353 | pubmed:author | pubmed-author:LeicherTT | lld:pubmed |
| pubmed-article:10454353 | pubmed:issnType | Print | lld:pubmed |
