| pubmed-article:10453038 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10453038 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10453038 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10453038 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:10453038 | lifeskim:mentions | umls-concept:C0085236 | lld:lifeskim |
| pubmed-article:10453038 | lifeskim:mentions | umls-concept:C0273115 | lld:lifeskim |
| pubmed-article:10453038 | lifeskim:mentions | umls-concept:C0003240 | lld:lifeskim |
| pubmed-article:10453038 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:10453038 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10453038 | pubmed:dateCreated | 1999-9-14 | lld:pubmed |
| pubmed-article:10453038 | pubmed:abstractText | Macrolide antibiotics have unique immunomodulatory actions apart from antimicrobial properties. We studied the effects of macrolides on IgG immune complex (IgG-ICx)-induced lung injury in rats in vivo and in vitro. Intrapulmonary deposition of IgG-ICx produced a time-dependent increase in the concentration of NO in exhaled air. There were corresponding increases in the number of neutrophils accumulated into alveolar spaces, and lung wet-to-dry weight ratio. All of these changes were inhibited by pretreatment with erythromycin or josamycin, but not by amoxicillin or cephaclor. Incubation of cultured pulmonary alveolar macrophages caused up-regulation of NO production and expression of inducible NO synthase mRNA, an effect that was dose dependently inhibited by erythromycin, roxithromycin, or josamycin. The macrolides also reduced IgG-ICx-induced release of IL-1beta and TNF-alpha, but did not alter the release of NO induced by exogenously added IL-1beta and TNF-alpha. These results suggest that macrolide antibiotics specifically inhibit immune complex-induced lung injury presumably by inhibiting cytokine release and the resultant down-regulation of inducible NO synthase gene expression and NO production by rat pulmonary alveolar macrophages. | lld:pubmed |
| pubmed-article:10453038 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10453038 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10453038 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10453038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10453038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10453038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10453038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10453038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10453038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10453038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10453038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10453038 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10453038 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10453038 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10453038 | pubmed:author | pubmed-author:KondoMM | lld:pubmed |
| pubmed-article:10453038 | pubmed:author | pubmed-author:KohriKK | lld:pubmed |
| pubmed-article:10453038 | pubmed:author | pubmed-author:NagaiAA | lld:pubmed |
| pubmed-article:10453038 | pubmed:author | pubmed-author:TamaokiJJ | lld:pubmed |
| pubmed-article:10453038 | pubmed:author | pubmed-author:AoshibaKK | lld:pubmed |
| pubmed-article:10453038 | pubmed:author | pubmed-author:TagayaEE | lld:pubmed |
| pubmed-article:10453038 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10453038 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10453038 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10453038 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10453038 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10453038 | pubmed:pagination | 2909-15 | lld:pubmed |
| pubmed-article:10453038 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10453038 | pubmed:meshHeading | pubmed-meshheading:10453038... | lld:pubmed |
| pubmed-article:10453038 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10453038 | pubmed:articleTitle | Macrolide antibiotics protect against immune complex-induced lung injury in rats: role of nitric oxide from alveolar macrophages. | lld:pubmed |
| pubmed-article:10453038 | pubmed:affiliation | First Department of Medicine, Tokyo Women's Medical University School of Medicine, Japan. jtamaoki@xc4.so-net.ne.jp | lld:pubmed |
| pubmed-article:10453038 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10453038 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10453038 | lld:pubmed |
