| pubmed-article:10452831 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10452831 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:10452831 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:10452831 | lifeskim:mentions | umls-concept:C0225369 | lld:lifeskim |
| pubmed-article:10452831 | lifeskim:mentions | umls-concept:C0521339 | lld:lifeskim |
| pubmed-article:10452831 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10452831 | lifeskim:mentions | umls-concept:C1157844 | lld:lifeskim |
| pubmed-article:10452831 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:10452831 | pubmed:issue | 9-10 | lld:pubmed |
| pubmed-article:10452831 | pubmed:dateCreated | 1999-9-23 | lld:pubmed |
| pubmed-article:10452831 | pubmed:abstractText | Interleukin-6 (IL-6) levels are markedly increased in the synovial fluid of patients with rheumatoid arthritis or osteoarthritis. However, the effects of IL-6 on proliferation and proteoglycan metabolism in articular cartilage are not known. We demonstrated here the effects of human recombinant (hr) IL-6 on proliferation and proteoglycan metabolism in rabbit articular chondrocyte cultures. In vitro, these cells proliferated and produced abundant extracellular matrices. We found that 1-10 ng/ml of hrIL-6 inhibited proliferation to approximately 65% of control levels and suppressed colony formation induced by bFGF in soft agarose. The same concentration of hrIL-6 depressed proteoglycan synthesis to approximately 60% of control levels. Moreover, hrIL-6 significantly enhanced proteoglycan degradation induced by hrIL-1beta, although hrIL-6 alone did not affect proteoglycan degradation. These findings suggest that IL-6 is a negative regulator for chondrocyte proliferation and articular cartilage metabolism. | lld:pubmed |
| pubmed-article:10452831 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10452831 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10452831 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10452831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10452831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10452831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10452831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10452831 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10452831 | pubmed:issn | 1065-6995 | lld:pubmed |
| pubmed-article:10452831 | pubmed:author | pubmed-author:KatoYY | lld:pubmed |
| pubmed-article:10452831 | pubmed:author | pubmed-author:MaedaTT | lld:pubmed |
| pubmed-article:10452831 | pubmed:author | pubmed-author:FuchihataHH | lld:pubmed |
| pubmed-article:10452831 | pubmed:author | pubmed-author:IwamotoMM | lld:pubmed |
| pubmed-article:10452831 | pubmed:author | pubmed-author:FujishitaMM | lld:pubmed |
| pubmed-article:10452831 | pubmed:author | pubmed-author:JikkoAA | lld:pubmed |
| pubmed-article:10452831 | pubmed:author | pubmed-author:WakisakaTT | lld:pubmed |
| pubmed-article:10452831 | pubmed:author | pubmed-author:HiranumaHH | lld:pubmed |
| pubmed-article:10452831 | pubmed:copyrightInfo | Copyright 1998 Academic Press. | lld:pubmed |
| pubmed-article:10452831 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10452831 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:10452831 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10452831 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10452831 | pubmed:pagination | 615-21 | lld:pubmed |
| pubmed-article:10452831 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10452831 | pubmed:meshHeading | pubmed-meshheading:10452831... | lld:pubmed |
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| pubmed-article:10452831 | pubmed:meshHeading | pubmed-meshheading:10452831... | lld:pubmed |
| pubmed-article:10452831 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:10452831 | pubmed:articleTitle | Effects of interleukin-6 on proliferation and proteoglycan metabolism in articular chondrocyte cultures. | lld:pubmed |
| pubmed-article:10452831 | pubmed:affiliation | Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan. | lld:pubmed |
| pubmed-article:10452831 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10452831 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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