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pubmed-article:10450974pubmed:abstractTextIndolequinone derivatives of the antitumour antibiotic BE 10988 were synthesized and evaluated for their cytotoxicity and action mechanism. The quinone system is essential to biological activity and the thiazole ring plays a major role in the poisoning of topoisomerase II.lld:pubmed
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pubmed-article:10450974pubmed:articleTitleSynthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II.lld:pubmed
pubmed-article:10450974pubmed:affiliationInstitut de Chimie Pharmaceutique, Université de Lille 2, France.lld:pubmed
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