| pubmed-article:10449440 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C0030520 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C0026046 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:10449440 | lifeskim:mentions | umls-concept:C0598850 | lld:lifeskim |
| pubmed-article:10449440 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10449440 | pubmed:dateCreated | 1999-9-14 | lld:pubmed |
| pubmed-article:10449440 | pubmed:abstractText | Renal proximal tubule cells express in their apical brush border membrane (BBM) a Na/P(i) cotransporter type IIa that is rapidly downregulated in response to parathyroid hormone (PTH). We used the rat renal Na/P(i) cotransporter type IIa (NaPi-2) as an in vivo model to assess early cellular events in the rapid downregulation of this transporter. When rats were treated with PTH for 15 minutes, NaPi-2 abundance in the BBM was decreased. In parallel, transporter accumulated in intracellular vesicles. Concomitantly, microtubules (MTs) were found to form dense bundles of apical-to-basal orientation. After 60 minutes of PTH action, the cells were vastly depleted of NaPi-2, whereas their microtubular cytoskeleton had returned to its normal appearance. Prevention of MT rearrangement by taxol resulted in accumulation of NaPi-2 in the subapical cell portion after 15 minutes and a strong delay in depletion of intracellular transporter after 60 minutes of PTH action. Furthermore, the subapical accumulation of NaPi-2 was associated with the expansion of dense apical tubules of the subapical endocytic apparatus (SEA). Depolymerization of MTs by colchicine likewise caused a retardation of intracellular NaPi-2 depletion. These results suggest that NaPi-2 is downregulated in response to PTH through a rapid endocytic process in 2 separate steps: (a) internalization of the transporter into the SEA, and (b) its delivery to degradative organelles by a trafficking mechanism whose efficiency depends on a taxol-sensitive rearrangement of MTs. | lld:pubmed |
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| pubmed-article:10449440 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10449440 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10449440 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10449440 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10449440 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10449440 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:10449440 | pubmed:author | pubmed-author:MurerHH | lld:pubmed |
| pubmed-article:10449440 | pubmed:author | pubmed-author:BiberJJ | lld:pubmed |
| pubmed-article:10449440 | pubmed:author | pubmed-author:WangHH | lld:pubmed |
| pubmed-article:10449440 | pubmed:author | pubmed-author:LeviMM | lld:pubmed |
| pubmed-article:10449440 | pubmed:author | pubmed-author:KaisslingBB | lld:pubmed |
| pubmed-article:10449440 | pubmed:author | pubmed-author:LötscherMM | lld:pubmed |
| pubmed-article:10449440 | pubmed:author | pubmed-author:ZajicekH KHK | lld:pubmed |
| pubmed-article:10449440 | pubmed:author | pubmed-author:HalaihelNN | lld:pubmed |
| pubmed-article:10449440 | pubmed:author | pubmed-author:ScarpettaYY | lld:pubmed |
| pubmed-article:10449440 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10449440 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:10449440 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10449440 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10449440 | pubmed:pagination | 483-94 | lld:pubmed |
| pubmed-article:10449440 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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