| pubmed-article:10441328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10441328 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10441328 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:10441328 | lifeskim:mentions | umls-concept:C0752125 | lld:lifeskim |
| pubmed-article:10441328 | lifeskim:mentions | umls-concept:C0665827 | lld:lifeskim |
| pubmed-article:10441328 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:10441328 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10441328 | pubmed:dateCreated | 2000-1-27 | lld:pubmed |
| pubmed-article:10441328 | pubmed:abstractText | Spinocerebellar ataxia type 7 (SCA7) belongs to a group of neurological disorders caused by a CAG repeat expansion in the coding region of the associated gene. To gain insight into the pathogenesis of SCA7 and possible functions of ataxin-7, we examined the subcellular localization of ataxin-7 in transfected COS-1 cells using SCA7 cDNA clones with different CAG repeat tract lengths. In addition to a diffuse distribution throughout the nucleus, ataxin-7 associated with the nuclear matrix and the nucleolus. The location of the putative SCA7 nuclear localization sequence (NLS) was confirmed by fusing an ataxin-7 fragment with the normally cytoplasmic protein chicken muscle pyruvate kinase. Mutation of this NLS prevented protein from entering the nucleus. Thus, expanded ataxin-7 may carry out its pathogenic effects in the nucleus by altering a matrix-associated nuclear structure and/or by disrupting nucleolar function. | lld:pubmed |
| pubmed-article:10441328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10441328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10441328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10441328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10441328 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10441328 | pubmed:issn | 0964-6906 | lld:pubmed |
| pubmed-article:10441328 | pubmed:author | pubmed-author:OrrH THT | lld:pubmed |
| pubmed-article:10441328 | pubmed:author | pubmed-author:RanumL PLP | lld:pubmed |
| pubmed-article:10441328 | pubmed:author | pubmed-author:DuvickL ALA | lld:pubmed |
| pubmed-article:10441328 | pubmed:author | pubmed-author:KoobM DMD | lld:pubmed |
| pubmed-article:10441328 | pubmed:author | pubmed-author:SkinnerP JPJ | lld:pubmed |
| pubmed-article:10441328 | pubmed:author | pubmed-author:KaytorM DMD | lld:pubmed |
| pubmed-article:10441328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10441328 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:10441328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10441328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10441328 | pubmed:pagination | 1657-64 | lld:pubmed |
| pubmed-article:10441328 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10441328 | pubmed:meshHeading | pubmed-meshheading:10441328... | lld:pubmed |
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| pubmed-article:10441328 | pubmed:meshHeading | pubmed-meshheading:10441328... | lld:pubmed |
| pubmed-article:10441328 | pubmed:meshHeading | pubmed-meshheading:10441328... | lld:pubmed |
| pubmed-article:10441328 | pubmed:meshHeading | pubmed-meshheading:10441328... | lld:pubmed |
| pubmed-article:10441328 | pubmed:meshHeading | pubmed-meshheading:10441328... | lld:pubmed |
| pubmed-article:10441328 | pubmed:meshHeading | pubmed-meshheading:10441328... | lld:pubmed |
| pubmed-article:10441328 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10441328 | pubmed:articleTitle | Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7. | lld:pubmed |
| pubmed-article:10441328 | pubmed:affiliation | Institute of Human Genetics, University of Minnesota, Minneapolis 55455, USA. | lld:pubmed |
| pubmed-article:10441328 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10441328 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:6314 | entrezgene:pubmed | pubmed-article:10441328 | lld:entrezgene |
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