| pubmed-article:10436256 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10436256 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:10436256 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:10436256 | lifeskim:mentions | umls-concept:C0039840 | lld:lifeskim |
| pubmed-article:10436256 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:10436256 | pubmed:dateCreated | 2000-4-5 | lld:pubmed |
| pubmed-article:10436256 | pubmed:abstractText | Thiamine plays an important role in the regulation of glucose metabolism and pancreatic beta-cell functioning. A role for this vitamin in cellular glucose transport has been indicated in the literature. The aim of this study was to determine whether a lipophilic form of thiamine (benzoyloxymethyl-thiamine, BOM) was able to improve metabolic control in patients with long-standing insulin-dependent diabetes mellitus (type 1). A total of 10 children with type 1 diabetes of long duration (age 11.4 +/- 1.2 years, duration of the disease 4.5 +/- 0.7 years, means +/- SEM) were studied before and after treatment with BOM in a randomized double-blind and placebo-controlled study. Five patients were assigned to the BOM-treated group and five to the placebo-group. In all patients basal and glucagon-stimulated C-peptide secretion was undetectable. Thiamine status was assayed by measuring the plasma content of thiamine and its monophosphate form at entry and after 3 months of treatment. The blood HbA(1C) levels and the daily dose of insulin per kg body weight were assessed in both groups before treatment, after 1 month and 3 months of treatment, then 3 months following its suspension. The plasma content of thiamine + thiamine monophosphate in type 1 diabetic patients (35.3 +/- 3.6 pmol/mL) was significantly lower when compared with that measured in six age-matched normal subjects (53.2 +/- 2.3 pmol/mL, P < 0.05). | lld:pubmed |
| pubmed-article:10436256 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10436256 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10436256 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10436256 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10436256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10436256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10436256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10436256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10436256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10436256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10436256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10436256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10436256 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10436256 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10436256 | pubmed:issn | 0940-5429 | lld:pubmed |
| pubmed-article:10436256 | pubmed:author | pubmed-author:TenoreAA | lld:pubmed |
| pubmed-article:10436256 | pubmed:author | pubmed-author:ValerioGG | lld:pubmed |
| pubmed-article:10436256 | pubmed:author | pubmed-author:PatriniCC | lld:pubmed |
| pubmed-article:10436256 | pubmed:author | pubmed-author:PoggiVV | lld:pubmed |
| pubmed-article:10436256 | pubmed:author | pubmed-author:FranzeseAA | lld:pubmed |
| pubmed-article:10436256 | pubmed:author | pubmed-author:LaforenzaUU | lld:pubmed |
| pubmed-article:10436256 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10436256 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:10436256 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10436256 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10436256 | pubmed:pagination | 73-6 | lld:pubmed |
| pubmed-article:10436256 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:10436256 | pubmed:meshHeading | pubmed-meshheading:10436256... | lld:pubmed |
| pubmed-article:10436256 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10436256 | pubmed:articleTitle | Lipophilic thiamine treatment in long-standing insulin-dependent diabetes mellitus. | lld:pubmed |
| pubmed-article:10436256 | pubmed:affiliation | Department of Pediatrics, P.le S. Maria della Misericordia, I-33100 Udine, Italy. | lld:pubmed |
| pubmed-article:10436256 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10436256 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10436256 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10436256 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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