| pubmed-article:10434846 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10434846 | lifeskim:mentions | umls-concept:C0032098 | lld:lifeskim |
| pubmed-article:10434846 | lifeskim:mentions | umls-concept:C0946611 | lld:lifeskim |
| pubmed-article:10434846 | lifeskim:mentions | umls-concept:C0162747 | lld:lifeskim |
| pubmed-article:10434846 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10434846 | lifeskim:mentions | umls-concept:C1548559 | lld:lifeskim |
| pubmed-article:10434846 | lifeskim:mentions | umls-concept:C0443324 | lld:lifeskim |
| pubmed-article:10434846 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10434846 | pubmed:dateCreated | 1999-8-16 | lld:pubmed |
| pubmed-article:10434846 | pubmed:abstractText | Coriandrum sativum (coriander) has been documented as a traditional treatment of diabetes. In the present study, coriander incorporated into the diet (62.5 g/kg) and drinking water (2.5 g/l, prepared by 15 min decoction) reduced hyperglycaemia of streptozotocin-diabetic mice. An aqueous extract of coriander (1 mg/ml) increased 2-deoxyglucose transport (1.6-fold), glucose oxidation (1.4-fold) and incorporation of glucose into glycogen (1.7-fold) of isolated murine abdominal muscle comparable with 10(-8) M-insulin. In acute 20 min tests, 0.25-10 mg/ml aqueous extract of coriander evoked a stepwise 1.3-5.7-fold stimulation of insulin secretion from a clonal B-cell line. This effect was abolished by 0.5 mM-diazoxide and prior exposure to extract did not alter subsequent stimulation of insulin secretion by 10 mM-L-alanine, thereby negating an effect due to detrimental cell damage. The effect of extract was potentiated by 16.7 mM-glucose and 10 mM-L-alanine but not by 1 mM-3-isobutyl-1-methylxanthine. Insulin secretion by hyperpolarized B-cells (16.7 mM-glucose, 25 mM-KCl) was further enhanced by the presence of extract. Activity of the extract was found to be heat stable, acetone soluble and unaltered by overnight exposure to acid (0.1 M-HCl) or dialysis to remove components with molecular mass < 2000 Da. Activity was reduced by overnight exposure to alkali (0.1 M-NaOH). Sequential extraction with solvents revealed insulin-releasing activity in hexane and water fractions indicating a possible cumulative effect of more than one extract constituent. These results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in Coriandrum sativum. | lld:pubmed |
| pubmed-article:10434846 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10434846 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10434846 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10434846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10434846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10434846 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10434846 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10434846 | pubmed:issn | 0007-1145 | lld:pubmed |
| pubmed-article:10434846 | pubmed:author | pubmed-author:GrayA MAM | lld:pubmed |
| pubmed-article:10434846 | pubmed:author | pubmed-author:FlattP RPR | lld:pubmed |
| pubmed-article:10434846 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10434846 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:10434846 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10434846 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10434846 | pubmed:pagination | 203-9 | lld:pubmed |
| pubmed-article:10434846 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:10434846 | pubmed:meshHeading | pubmed-meshheading:10434846... | lld:pubmed |
| pubmed-article:10434846 | pubmed:meshHeading | pubmed-meshheading:10434846... | lld:pubmed |
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| pubmed-article:10434846 | pubmed:meshHeading | pubmed-meshheading:10434846... | lld:pubmed |
| pubmed-article:10434846 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10434846 | pubmed:articleTitle | Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). | lld:pubmed |
| pubmed-article:10434846 | pubmed:affiliation | School of Biomedical Sciences, University of Ulster, Coleraine, UK. youngheartsproject@hpsspop.n-i.nhs.uk | lld:pubmed |
| pubmed-article:10434846 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10434846 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10434846 | lld:pubmed |
