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pubmed-article:10429986pubmed:abstractTextCytokines are important regulators of immune and inflammatory reactions in the skin, and may contribute to inflammatory blister induction. We examined the profiles of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in fluid of spontaneous blisters in the immune-based inflammatory disorders bullous pemphigoid (8 patients), allergic contact dermatitis (5 patients) and toxic epidermal necrolysis (5 patients). These were compared with levels in 9 patients with burns, i.e. inflammatory blisters of non-immune aetiology, and 4 patients with blisters of physical origin. Very high levels of IL-6 were found in bullous pemphigoid and toxic epidermal necrolysis (p<0.001) compared with non-inflammatory and burn blisters. TNF-alpha levels were high in bullous pemphigoid and burns, but undetectable in non-inflammatory blisters. The pattern in bullous pemphigoid (very high IL-6, high TNF-alpha) differed substantially from toxic epidermal necrolysis (very high IL-6, low TNF-alpha), while burns and allergic contact dermatitis showed lesser elevation of both cytokines. Hence, differences in cytokine profiles were identified, although the relevance to underlying pathomechanisms is uncertain.lld:pubmed
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pubmed-article:10429986pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:10429986pubmed:articleTitleBlister fluid cytokines in cutaneous inflammatory bullous disorders.lld:pubmed
pubmed-article:10429986pubmed:affiliationDepartment of Dermatology, University of Liverpool, UK.lld:pubmed
pubmed-article:10429986pubmed:publicationTypeJournal Articlelld:pubmed
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