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pubmed-article:10428628pubmed:abstractTextExperimental vaccine trials against hydatid disease have been undertaken in sheep using the EG95 recombinant vaccine. Challenge infection was with viable Echinococcus granulosus eggs obtained from a New Zealand isolate (dog/sheep cycle), an Australian isolate (dingo/wallaby cycle) and an Argentine isolate (dog/sheep cycle). Vaccination with EG95 conferred a high degree of protection against challenge with all three parasite isolates (protection range 96-100%). Taken together, the trials demonstrated that 86% of vaccinated sheep were completely free of viable hydatid cysts when examined approximately 1 year after challenge infection. Vaccination reduced the number of viable cysts by 99.3% compared with unvaccinated controls. These results suggest that the EG95 vaccine could have wide applicability as a new tool for use in hydatid control campaigns.lld:pubmed
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pubmed-article:10428628pubmed:articleTitleVaccination trials in Australia and Argentina confirm the effectiveness of the EG95 hydatid vaccine in sheep.lld:pubmed
pubmed-article:10428628pubmed:affiliationMolecular Parasitology Laboratory, The University of Melbourne, Vic. Australia. marshall@unimelb.edu.aulld:pubmed
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