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pubmed-article:10422874pubmed:abstractTextThe effects of atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32) and C-type natriuretic peptide (CNP-22) on body temperature were investigated in rats. Intracerebroventricular administration of each peptide in doses of 400 or 1000 ng caused a dose-related elevation in colon temperature 30 and 60 min after injection. A 40 ng dose of ANP-28 was also hyperthermic at 60 min. An intramuscular (i.m.) injection of noraminophenazone (a cyclooxygenase inhibitor) abolished the natriuretic peptide-induced hyperthermia. The results show that natriuretic peptides may participate in thermoregulatory processes in the central nervous system, and that their hyperthermic effect may be mediated via a cyclooxygenase-involved pathway.lld:pubmed
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pubmed-article:10422874pubmed:articleTitleHyperthermic effect of centrally administered natriuretic peptides in the rat.lld:pubmed
pubmed-article:10422874pubmed:affiliationDepartment of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.lld:pubmed
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pubmed-article:10422874pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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