| pubmed-article:10422197 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10422197 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:10422197 | lifeskim:mentions | umls-concept:C0001349 | lld:lifeskim |
| pubmed-article:10422197 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:10422197 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10422197 | pubmed:dateCreated | 1999-9-20 | lld:pubmed |
| pubmed-article:10422197 | pubmed:abstractText | The acute-phase reaction comprises a variety of systemic changes in response to tissue injury and infection. Synthesis of several plasma proteins in the liver undergoes dramatic changes during the acute-phase reaction. These changes are mediated by the action of cytokines, mainly interleukin 6-(IL6-) and interleukin 1-(IL1-) type cytokines. The role of these cytokines is reviewed in detail. Attention is payed to the differences recently detected between the locally and systemically induced acute-phase response--in particular, the newest findings concerning the meaning of single cytokines. Also, changes in liver metabolic enzyme expression under acute-phase conditions are discussed. The impact of cytokine and cytokine-receptor knockout or transgenic mouse models on current knowledge is provided. The role of cytokines together with that of soluble cytokine receptors in the resolution of the acute-phase response is discussed. | lld:pubmed |
| pubmed-article:10422197 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10422197 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10422197 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10422197 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10422197 | pubmed:issn | 0272-8087 | lld:pubmed |
| pubmed-article:10422197 | pubmed:author | pubmed-author:ChristBB | lld:pubmed |
| pubmed-article:10422197 | pubmed:author | pubmed-author:RamadoriGG | lld:pubmed |
| pubmed-article:10422197 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10422197 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10422197 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10422197 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10422197 | pubmed:pagination | 141-55 | lld:pubmed |
| pubmed-article:10422197 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10422197 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10422197 | pubmed:articleTitle | Cytokines and the hepatic acute-phase response. | lld:pubmed |
| pubmed-article:10422197 | pubmed:affiliation | Department of Gastroenterology and Endocrinology, University of Göttingen, Germany. | lld:pubmed |
| pubmed-article:10422197 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10422197 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:10422197 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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