| pubmed-article:10421629 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10421629 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:10421629 | lifeskim:mentions | umls-concept:C1158884 | lld:lifeskim |
| pubmed-article:10421629 | lifeskim:mentions | umls-concept:C1332359 | lld:lifeskim |
| pubmed-article:10421629 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:10421629 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:10421629 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:10421629 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:10421629 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:10421629 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:10421629 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:10421629 | pubmed:dateCreated | 1999-8-19 | lld:pubmed |
| pubmed-article:10421629 | pubmed:abstractText | The stabilization of beta-catenin is a key regulatory step during cell fate changes and transformations to tumor cells. Several interacting proteins, including Axin, APC, and the protein kinase GSK-3beta are implicated in regulating beta-catenin phosphorylation and its subsequent degradation. Wnt signaling stabilizes beta-catenin, but it was not clear whether and how Wnt signaling regulates the beta-catenin complex. Here we show that Axin is dephosphorylated in response to Wnt signaling. The dephosphorylated Axin binds beta-catenin less efficiently than the phosphorylated form. Thus, Wnt signaling lowers Axin's affinity for beta-catenin, thereby disengaging beta-catenin from the degradation machinery. | lld:pubmed |
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| pubmed-article:10421629 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10421629 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10421629 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10421629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10421629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10421629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10421629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10421629 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10421629 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10421629 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:10421629 | pubmed:author | pubmed-author:NusseRR | lld:pubmed |
| pubmed-article:10421629 | pubmed:author | pubmed-author:WillersJJ | lld:pubmed |
| pubmed-article:10421629 | pubmed:author | pubmed-author:ShibamotoSS | lld:pubmed |
| pubmed-article:10421629 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10421629 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10421629 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:10421629 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10421629 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10421629 | pubmed:pagination | 1768-73 | lld:pubmed |
| pubmed-article:10421629 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:10421629 | pubmed:meshHeading | pubmed-meshheading:10421629... | lld:pubmed |
| pubmed-article:10421629 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10421629 | pubmed:articleTitle | Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. | lld:pubmed |
| pubmed-article:10421629 | pubmed:affiliation | Howard Hughes Medical Institute (HHMI) and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 USA. | lld:pubmed |
| pubmed-article:10421629 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10421629 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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