| pubmed-article:10420004 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10420004 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10420004 | lifeskim:mentions | umls-concept:C0029246 | lld:lifeskim |
| pubmed-article:10420004 | lifeskim:mentions | umls-concept:C0041412 | lld:lifeskim |
| pubmed-article:10420004 | lifeskim:mentions | umls-concept:C0009195 | lld:lifeskim |
| pubmed-article:10420004 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:10420004 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:10420004 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:10420004 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10420004 | pubmed:dateCreated | 1999-10-4 | lld:pubmed |
| pubmed-article:10420004 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10420004 | pubmed:abstractText | 1. Turtle auditory hair cells contain multiple isoforms of the pore-forming alpha-subunit of the large-conductance Ca2+-activated K+ (KCa) channel due to alternative splicing at two sites. Six splice variants were studied by expression in Xenopus oocytes. 2. The isoforms possessed differences in apparent Ca2+ sensitivity and kinetics. The lowest Ca2+ sensitivity was observed in a novel variant resulting from a 26 amino acid deletion around one of the splice sites. 3. Co-expression of a bovine beta-subunit slowed the current relaxation 10-fold compared with channels formed from alpha-subunits alone but preserved the original order of kinetic differences. The beta-subunit also increased the Ca2+ sensitivity of isoforms to bring them nearer the range of sensitivity of the native KCa channels of the hair cell. 4. With channels formed from alpha-subunits or alpha + beta-subunits, the half-activation voltage in a fixed Ca2+ concentration, and the time constant of the current relaxation, varied linearly with the combined size of the insertions/deletions at the splice sites. 5. Experiments in which the beta/alpha concentration ratio was varied indicated that the beta-subunit exerts an all-or-none effect on the Ca2+ sensitivity and kinetics of the channel. 6. Co-expression of an avian beta2-subunit had effects on kinetics and Ca2+ sensitivity of several alpha-isoforms which were qualitatively similar to those produced by the bovine beta-subunit. 7. We conclude that differential expression of alternatively spliced alpha-subunit variants and a non-uniform distribution of a beta-subunit can produce a range of KCa channel properties needed to explain the tonotopic organization of the turtle cochlea. | lld:pubmed |
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| pubmed-article:10420004 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10420004 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10420004 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10420004 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10420004 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:10420004 | pubmed:author | pubmed-author:FettiplaceRR | lld:pubmed |
| pubmed-article:10420004 | pubmed:author | pubmed-author:JonesE MEM | lld:pubmed |
| pubmed-article:10420004 | pubmed:author | pubmed-author:Gray-KellerMM | lld:pubmed |
| pubmed-article:10420004 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10420004 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10420004 | pubmed:volume | 518 ( Pt 3) | lld:pubmed |
| pubmed-article:10420004 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10420004 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10420004 | pubmed:pagination | 653-65 | lld:pubmed |
| pubmed-article:10420004 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10420004 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10420004 | pubmed:articleTitle | The role of Ca2+-activated K+ channel spliced variants in the tonotopic organization of the turtle cochlea. | lld:pubmed |
| pubmed-article:10420004 | pubmed:affiliation | Department of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA. | lld:pubmed |
| pubmed-article:10420004 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10420004 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10420004 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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