| pubmed-article:10417378 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10417378 | lifeskim:mentions | umls-concept:C2717939 | lld:lifeskim |
| pubmed-article:10417378 | lifeskim:mentions | umls-concept:C0443301 | lld:lifeskim |
| pubmed-article:10417378 | lifeskim:mentions | umls-concept:C1420737 | lld:lifeskim |
| pubmed-article:10417378 | pubmed:issue | 5427 | lld:pubmed |
| pubmed-article:10417378 | pubmed:dateCreated | 1999-8-12 | lld:pubmed |
| pubmed-article:10417378 | pubmed:abstractText | Most organisms have circadian clocks consisting of negative feedback loops of gene regulation that facilitate adaptation to cycles of light and darkness. In this study, CRYPTOCHROME (CRY), a protein involved in circadian photoperception in Drosophila, is shown to block the function of PERIOD/TIMELESS (PER/TIM) heterodimeric complexes in a light-dependent fashion. TIM degradation does not occur under these conditions; thus, TIM degradation is uncoupled from abrogation of its function by light. CRY and TIM are part of the same complex and directly interact in yeast in a light-dependent fashion. PER/TIM and CRY influence the subcellular distribution of these protein complexes, which reside primarily in the nucleus after the perception of a light signal. Thus, CRY acts as a circadian photoreceptor by directly interacting with core components of the circadian clock. | lld:pubmed |
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| pubmed-article:10417378 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10417378 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10417378 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10417378 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10417378 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:10417378 | pubmed:author | pubmed-author:LauR ERE | lld:pubmed |
| pubmed-article:10417378 | pubmed:author | pubmed-author:WeitzC JCJ | lld:pubmed |
| pubmed-article:10417378 | pubmed:author | pubmed-author:StaknisDD | lld:pubmed |
| pubmed-article:10417378 | pubmed:author | pubmed-author:CerianiM FMF | lld:pubmed |
| pubmed-article:10417378 | pubmed:author | pubmed-author:MásPP | lld:pubmed |
| pubmed-article:10417378 | pubmed:author | pubmed-author:DarlingtonT... | lld:pubmed |
| pubmed-article:10417378 | pubmed:author | pubmed-author:PettiA AAA | lld:pubmed |
| pubmed-article:10417378 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10417378 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:10417378 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:10417378 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10417378 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10417378 | pubmed:pagination | 553-6 | lld:pubmed |
| pubmed-article:10417378 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10417378 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10417378 | pubmed:articleTitle | Light-dependent sequestration of TIMELESS by CRYPTOCHROME. | lld:pubmed |
| pubmed-article:10417378 | pubmed:affiliation | Department of Cell Biology and NSF Center for Biological Timing, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:10417378 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10417378 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10417378 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10417378 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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