| pubmed-article:10411897 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10411897 | lifeskim:mentions | umls-concept:C0023768 | lld:lifeskim |
| pubmed-article:10411897 | lifeskim:mentions | umls-concept:C0037812 | lld:lifeskim |
| pubmed-article:10411897 | lifeskim:mentions | umls-concept:C0016315 | lld:lifeskim |
| pubmed-article:10411897 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:10411897 | lifeskim:mentions | umls-concept:C0242842 | lld:lifeskim |
| pubmed-article:10411897 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:10411897 | lifeskim:mentions | umls-concept:C0585064 | lld:lifeskim |
| pubmed-article:10411897 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:10411897 | pubmed:dateCreated | 1999-8-23 | lld:pubmed |
| pubmed-article:10411897 | pubmed:abstractText | We report the application of confocal imaging and fluorescence correlation spectroscopy (FCS) to characterize chemically well-defined lipid bilayer models for biomembranes. Giant unilamellar vesicles of dilauroyl phosphatidylcholine/dipalmitoyl phosphatidylcholine (DLPC/DPPC)/cholesterol were imaged by confocal fluorescence microscopy with two fluorescent probes, 1, 1'-dieicosanyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI-C(20)) and 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a, 4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycero-3 -phosphoc holine (Bodipy-PC). Phase separation was visualized by differential probe partition into the coexisting phases. Three-dimensional image reconstructions of confocal z-scans through giant unilamellar vesicles reveal the anisotropic morphology of coexisting phase domains on the surface of these vesicles with full two-dimensional resolution. This method demonstrates by direct visualization the exact superposition of like phase domains in apposing monolayers, thus answering a long-standing open question. Cholesterol was found to induce a marked change in the phase boundary shapes of the coexisting phase domains. To further characterize the phases, the translational diffusion coefficient, D(T), of the DiI-C(20) was measured by FCS. D(T) values at approximately 25 degrees C ranged from approximately 3 x 10(-8) cm(2)/s in the fluid phase, to approximately 2 x 10(-9) cm(2)/s in high-cholesterol-content phases, to approximately 2 x 10(-10) cm(2)/s in the spatially ordered phases that coexist with fluid phases. In favorable cases, FCS could distinguish two different values of D(T) in a region of two-phase coexistence on a single vesicle. | lld:pubmed |
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| pubmed-article:10411897 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10411897 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411897 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10411897 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10411897 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10411897 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10411897 | pubmed:author | pubmed-author:SchwillePP | lld:pubmed |
| pubmed-article:10411897 | pubmed:author | pubmed-author:FeigensonG... | lld:pubmed |
| pubmed-article:10411897 | pubmed:author | pubmed-author:WebbW WWW | lld:pubmed |
| pubmed-article:10411897 | pubmed:author | pubmed-author:KorlachJJ | lld:pubmed |
| pubmed-article:10411897 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10411897 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:10411897 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10411897 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10411897 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10411897 | pubmed:pagination | 8461-6 | lld:pubmed |
| pubmed-article:10411897 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:10411897 | pubmed:meshHeading | pubmed-meshheading:10411897... | lld:pubmed |
| pubmed-article:10411897 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10411897 | pubmed:articleTitle | Characterization of lipid bilayer phases by confocal microscopy and fluorescence correlation spectroscopy. | lld:pubmed |
| pubmed-article:10411897 | pubmed:affiliation | Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA. | lld:pubmed |
| pubmed-article:10411897 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10411897 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10411897 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10411897 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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