| pubmed-article:10411485 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10411485 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:10411485 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:10411485 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:10411485 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10411485 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:10411485 | lifeskim:mentions | umls-concept:C0138837 | lld:lifeskim |
| pubmed-article:10411485 | lifeskim:mentions | umls-concept:C1532411 | lld:lifeskim |
| pubmed-article:10411485 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:10411485 | pubmed:dateCreated | 1999-8-2 | lld:pubmed |
| pubmed-article:10411485 | pubmed:abstractText | Farnesyl protein transferase (FPT) is a promising target for the development of cancer chemotherapeutics because it is responsible for the farnesylation of oncogenic p21 Ras proteins which are found in nearly 30% of all human cancers and necessary for cellular development and growth. The recent discovery and progression to phase II clinical trials of trihalobenzocycloheptapyridine Sch-66336 as a potent inhibitor of FPT with oral, in vivo efficacy in mice have spawned extensive structure-activity relationship studies (SAR) of this class of compounds. Of the many trihalobenzocycloheptapyridine analogues prepared, we have identified several which inhibit FPT and cellular proliferation at single-digit nanomolar concentrations and which have good pharmacokinetic properties in mice. | lld:pubmed |
| pubmed-article:10411485 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10411485 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411485 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10411485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10411485 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10411485 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10411485 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:AlvarezCC | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:LinDD | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:ChaoJJ | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:JamesLL | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:WangLL | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:CaroAA | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:GangulyA KAK | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:DollR JRJ | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:MallamsA KAK | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:PinteFF | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:AfonsoAA | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:BishopW RWR | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:PramanikBB | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:Girijavallabh... | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:KirschmeierPP | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:NjorogeF GFG | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:del RosarioJJ | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:HeimarkLL | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:RossmanR RRR | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:VibulbhanBB | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:TaverasA GAG | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:RemiszewskiSS | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:DeskusJJ | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:VaccaroC JCJ | lld:pubmed |
| pubmed-article:10411485 | pubmed:author | pubmed-author:LalwaniTT | lld:pubmed |
| pubmed-article:10411485 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10411485 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10411485 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:10411485 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10411485 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:10411485 | pubmed:pagination | 2651-61 | lld:pubmed |
| pubmed-article:10411485 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10411485 | pubmed:meshHeading | pubmed-meshheading:10411485... | lld:pubmed |
| pubmed-article:10411485 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10411485 | pubmed:articleTitle | Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities. | lld:pubmed |
| pubmed-article:10411485 | pubmed:affiliation | Anti-infectives and Tumor Biology Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. | lld:pubmed |
| pubmed-article:10411485 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:10411485 | lld:chembl |
