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pubmed-article:10405229pubmed:abstractTextAlthough Epstein-Barr virus (EBV) has been reported to be present in some 7% of gastric carcinomas, the nature of the background gastric mucosa of carcinoma has not been elucidated. The authors evaluated the degree of gastritis in the background gastric mucosa of EBV-associated gastric carcinoma. EBV was detected using in situ hybridization for EBV-encoded small ribonucleic acid 1 (EBER-1) in carcinoma cells. The authors compared gastritis in surgically resected stomachs with 8 EBER-1-positive and 16 EBER-1-negative gastric carcinomas of a similar histologic type using histologic variables of the Updated Sydney System. All eight lesions of EBER-1-positive gastric carcinomas had intestinal metaplasia in the background. Mild to moderate glandular atrophy was common in both groups. Many of the tested lesions, 87.5% of EBER-1-positive and 62.5% of EBER-1-negative lesions, were located near the mucosal atrophic border. The background gastric mucosa for EBV-associated gastric carcinomas is rich in atrophic changes. EBV-associated gastric carcinomas are located near the mucosal atrophic border.lld:pubmed
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pubmed-article:10405229pubmed:pagination39-43lld:pubmed
pubmed-article:10405229pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10405229pubmed:year1999lld:pubmed
pubmed-article:10405229pubmed:articleTitleEpstein-Barr virus-associated gastric carcinoma and atrophic gastritis.lld:pubmed
pubmed-article:10405229pubmed:affiliationFirst Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan.lld:pubmed
pubmed-article:10405229pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10405229pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:10405229pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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