| pubmed-article:10404829 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10404829 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10404829 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:10404829 | lifeskim:mentions | umls-concept:C0232552 | lld:lifeskim |
| pubmed-article:10404829 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10404829 | lifeskim:mentions | umls-concept:C1121637 | lld:lifeskim |
| pubmed-article:10404829 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10404829 | pubmed:dateCreated | 1999-7-26 | lld:pubmed |
| pubmed-article:10404829 | pubmed:abstractText | Glucagon-like peptide (GLP)-2 is formed from proglucagon in the intestinal L cells and is secreted postprandially in parallel with the insulinotropic hormone GLP-1, the latter of which, in addition, acts to inhibit gastric secretion and motility by inhibiting central parasympathetic outflow. We now studied the effect of GLP-2 on gastric secretion stimulated by sham feeding to test the hypothesis that also GLP-2 acts as an enterogastrone. Eight healthy volunteers were studied twice on separate days. They were sham fed with and without GLP-2 infused iv at a rate of 0.8 pmol/kg x min. Gastric contents were aspirated continuously by a nasogastric tube for determination of acid secretion, volume, and osmolarity. Sham feeding increased gastric acid secretion nearly 5-fold. Infusion of GLP-2 reduced incremental acid secretion by 65+/-6%, compared with saline infusion (delta8.75+/-0.37 vs. delta3.04+/-0.47 mmol x 60 min; P<0.01). Plasma concentrations of GLP-2 rose from a basal mean of 3.3+/-0.9 to a mean of 115+/-8 pmol/L (range, 57-149 pmol/L) during infusion of GLP-2 and remained at basal level during saline infusion. Plasma concentrations of GLP-1, gastrin, cholecystokinin, and secretin remained low and unchanged on both study days. We conclude that GLP-2 is a powerful inhibitor of gastric acid secretion in man. Further investigations will show to what extent GLP-2 contributes to the inhibitory effects on gastric secretion exerted by hormones from the distal small intestine, under physiological circumstances. | lld:pubmed |
| pubmed-article:10404829 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10404829 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10404829 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10404829 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10404829 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10404829 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10404829 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:10404829 | pubmed:author | pubmed-author:HolstJ JJJ | lld:pubmed |
| pubmed-article:10404829 | pubmed:author | pubmed-author:HartmannBB | lld:pubmed |
| pubmed-article:10404829 | pubmed:author | pubmed-author:HilstedLL | lld:pubmed |
| pubmed-article:10404829 | pubmed:author | pubmed-author:WettergrenAA | lld:pubmed |
| pubmed-article:10404829 | pubmed:author | pubmed-author:WøjdemannMM | lld:pubmed |
| pubmed-article:10404829 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10404829 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:10404829 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10404829 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10404829 | pubmed:pagination | 2513-7 | lld:pubmed |
| pubmed-article:10404829 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10404829 | pubmed:meshHeading | pubmed-meshheading:10404829... | lld:pubmed |
| pubmed-article:10404829 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10404829 | pubmed:articleTitle | Inhibition of sham feeding-stimulated human gastric acid secretion by glucagon-like peptide-2. | lld:pubmed |
| pubmed-article:10404829 | pubmed:affiliation | Department of Surgery, Rigshospitalet, Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:10404829 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10404829 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10404829 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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