pubmed-article:10398605 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10398605 | lifeskim:mentions | umls-concept:C0043346 | lld:lifeskim |
pubmed-article:10398605 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
pubmed-article:10398605 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
pubmed-article:10398605 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
pubmed-article:10398605 | pubmed:issue | 5425 | lld:pubmed |
pubmed-article:10398605 | pubmed:dateCreated | 1999-7-27 | lld:pubmed |
pubmed-article:10398605 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10398605 | pubmed:abstractText | Xeroderma pigmentosum (XP) is an autosomal recessive disease characterized by a high incidence of skin cancers. Yeast RAD30 encodes a DNA polymerase involved in the error-free bypass of ultraviolet (UV) damage. Here it is shown that XP variant (XP-V) cell lines harbor nonsense or frameshift mutations in hRAD30, the human counterpart of yeast RAD30. Of the eight mutations identified, seven would result in a severely truncated hRad30 protein. These results indicate that defects in hRAD30 cause XP-V, and they suggest that error-free replication of UV lesions by hRad30 plays an important role in minimizing the incidence of sunlight-induced skin cancers. | lld:pubmed |
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pubmed-article:10398605 | pubmed:language | eng | lld:pubmed |
pubmed-article:10398605 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10398605 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:10398605 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10398605 | pubmed:month | Jul | lld:pubmed |
pubmed-article:10398605 | pubmed:issn | 0036-8075 | lld:pubmed |
pubmed-article:10398605 | pubmed:author | pubmed-author:PrakashLL | lld:pubmed |
pubmed-article:10398605 | pubmed:author | pubmed-author:PrakashSS | lld:pubmed |
pubmed-article:10398605 | pubmed:author | pubmed-author:JohnsonR ERE | lld:pubmed |
pubmed-article:10398605 | pubmed:author | pubmed-author:KondratickC... | lld:pubmed |
pubmed-article:10398605 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10398605 | pubmed:day | 9 | lld:pubmed |
pubmed-article:10398605 | pubmed:volume | 285 | lld:pubmed |
pubmed-article:10398605 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10398605 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10398605 | pubmed:pagination | 263-5 | lld:pubmed |
pubmed-article:10398605 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:10398605 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:10398605 | pubmed:articleTitle | hRAD30 mutations in the variant form of xeroderma pigmentosum. | lld:pubmed |
pubmed-article:10398605 | pubmed:affiliation | Sealy Center for Molecular Science, University of Texas Medical Branch at Galveston, 6.104 Medical Research Building, 11th and Mechanic Streets, Galveston, TX 77555-1061, USA. | lld:pubmed |
pubmed-article:10398605 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10398605 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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