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pubmed-article:10386925pubmed:abstractTextA new prodrug approach for intracellular delivery of phosphonates was developed via the synthesis of 3-phthalidyl esters of 1-naphthalenemethylphosphonate. This approach is advantageous over the traditional acyloxymethyl phosphonate prodrugs, because these prodrugs do not generate formaldehyde and have improved plasma half-lives.lld:pubmed
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pubmed-article:10386925pubmed:articleTitleSynthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates.lld:pubmed
pubmed-article:10386925pubmed:affiliationDepartment of Medicinal Chemistry, Metabasis Therapeutics, Inc., San Diego, CA 92121, USA.lld:pubmed
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