| pubmed-article:10384137 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10384137 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:10384137 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:10384137 | lifeskim:mentions | umls-concept:C0134835 | lld:lifeskim |
| pubmed-article:10384137 | lifeskim:mentions | umls-concept:C0078056 | lld:lifeskim |
| pubmed-article:10384137 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:10384137 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:10384137 | lifeskim:mentions | umls-concept:C0806140 | lld:lifeskim |
| pubmed-article:10384137 | lifeskim:mentions | umls-concept:C0348080 | lld:lifeskim |
| pubmed-article:10384137 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10384137 | pubmed:dateCreated | 1999-7-15 | lld:pubmed |
| pubmed-article:10384137 | pubmed:abstractText | This study examined the adhesive interaction of peripheral blood monocytes with VCAM-1 and analyzed the effect of P-selectin binding to monocytes on the adhesive interaction with VCAM-1 under flow conditions. P-selectin glycoprotein ligand-1 is expressed on most monocytes. Furthermore, most monocytes bind soluble P-selectin derived from platelets. P-selectin binding to monocytes did not alter the amount of expression of alpha4 integrin on monocytes. However, the mean channel fluorescence value for binding Cy2-conjugated soluble VCAM-1 to P-selectin-bound monocytes was slightly more than that for binding Cy2-conjugated soluble VCAM-1 to untreated monocytes. Under flow conditions, the number of P-selectin-bound monocytes bound to VCAM-1 was much higher than that of untreated monocytes bound to VCAM-1. These bindings were abolished by pretreatment of untreated monocytes and P-selectin-bound monocytes with anti-VCAM-1 mAb or anti-alpha4 integrin mAb. Furthermore, P-selectin binding to monocytes increased shear resistance and thus increased the adhesive strength of monocytes to VCAM-1. These findings indicate that P-selectin binding to monocytes enhances the adhesive interaction of monocytes with VCAM-1. It is suggested that P-selectin glycoprotein ligand-1/P-selectin interaction and alpha4 integrin/VCAM-1 interaction can act sequentially in the adhesion cascade that regulates monocyte trafficking to inflammatory and atherosclerotic lesion. | lld:pubmed |
| pubmed-article:10384137 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10384137 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10384137 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10384137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10384137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10384137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10384137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10384137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10384137 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10384137 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10384137 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10384137 | pubmed:author | pubmed-author:YagiNN | lld:pubmed |
| pubmed-article:10384137 | pubmed:author | pubmed-author:MinamiMM | lld:pubmed |
| pubmed-article:10384137 | pubmed:author | pubmed-author:TsukudaMM | lld:pubmed |
| pubmed-article:10384137 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10384137 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10384137 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10384137 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10384137 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10384137 | pubmed:pagination | 367-73 | lld:pubmed |
| pubmed-article:10384137 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:meshHeading | pubmed-meshheading:10384137... | lld:pubmed |
| pubmed-article:10384137 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10384137 | pubmed:articleTitle | P-selectin binding promotes the adhesion of monocytes to VCAM-1 under flow conditions. | lld:pubmed |
| pubmed-article:10384137 | pubmed:affiliation | Department of Otolaryngology, Yokohama City University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:10384137 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10384137 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10384137 | lld:pubmed |
