| pubmed-article:10381591 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10381591 | lifeskim:mentions | umls-concept:C1527169 | lld:lifeskim |
| pubmed-article:10381591 | lifeskim:mentions | umls-concept:C1304649 | lld:lifeskim |
| pubmed-article:10381591 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:10381591 | lifeskim:mentions | umls-concept:C0034650 | lld:lifeskim |
| pubmed-article:10381591 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:10381591 | lifeskim:mentions | umls-concept:C0018792 | lld:lifeskim |
| pubmed-article:10381591 | lifeskim:mentions | umls-concept:C1522565 | lld:lifeskim |
| pubmed-article:10381591 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10381591 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:10381591 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:10381591 | pubmed:dateCreated | 1999-10-20 | lld:pubmed |
| pubmed-article:10381591 | pubmed:abstractText | 1. The cardiac effects of the NO donors sodium nitroprusside (SNP), S-nitroso-N-acetyl-penicillamine (SNAP) and 3-morpholino-sydnonimine (SIN-1) were studied in frog fibres to evaluate the contribution of cyclic GMP-dependent mechanisms. 2. SNP and SNAP (0.1-100 microM) reduced the force of contraction in a concentration-dependent manner in atrial and ventricular fibres. This effect was associated with a reduction in the time to peak (TTP) and the time for half-relaxation of contraction (T). 3. SIN-1 (100 microM) also reduced the force of contraction in two-thirds of the atrial fibres. However, it exerted a positive inotropic effect in the remaining atrial fibres, as well as in most ventricular fibres. 4. The guanylyl cyclase inhibitor 1H-[1,2,4]oxidiazolo[4,3-a]quinoxaline-1-one (ODQ, 10 microM) antagonized the negative inotropic effects of SIN-1 (50 microM) and SNAP (25 microM) but had no effect on the positive inotropic response to SIN-1 (100 microM). 5. In the presence of SIN-1, superoxide dismutase (SOD, 50-200 U ml-1) either potentiated the negative inotropic effect or turned the positive inotropic effect of the drug into a negative effect. SOD had no effects when applied alone or in the presence of SNAP. 6. 6-Anilino-5,8-quinolinedione (LY 83583, 3-30 microM), a superoxide anion generator also known as a cyclic GMP-lowering agent, exerted a positive inotropic effect, which was antagonized by SOD (200-370 U ml-1) but not by ODQ (10 microM). 7. We conclude that SNP, SNAP and SIN-1 exert cyclic GMP-dependent negative inotropic effects, which are attributed to the generation of NO. In addition, SIN-1 and LY 83583 exert cyclic GMP-independent positive inotropic effects, which require the generation of superoxide anion. | lld:pubmed |
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| pubmed-article:10381591 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10381591 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381591 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10381591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10381591 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10381591 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10381591 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:10381591 | pubmed:author | pubmed-author:ChesnaisJ MJM | lld:pubmed |
| pubmed-article:10381591 | pubmed:author | pubmed-author:FischmeisterR... | lld:pubmed |
| pubmed-article:10381591 | pubmed:author | pubmed-author:MéryP FPF | lld:pubmed |
| pubmed-article:10381591 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10381591 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10381591 | pubmed:volume | 518 ( Pt 2) | lld:pubmed |
| pubmed-article:10381591 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10381591 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10381591 | pubmed:pagination | 449-61 | lld:pubmed |
| pubmed-article:10381591 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10381591 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10381591 | pubmed:articleTitle | Positive and negative inotropic effects of NO donors in atrial and ventricular fibres of the frog heart. | lld:pubmed |
| pubmed-article:10381591 | pubmed:affiliation | Laboratoire de Cardiologie Cellulaire et Moleculaire, INSERM U-446, Universite Paris-Sud, Faculte de Pharmacie, F-92296 Châtenay-Malabry, France. | lld:pubmed |
