| pubmed-article:10381171 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10381171 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:10381171 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:10381171 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:10381171 | lifeskim:mentions | umls-concept:C0008169 | lld:lifeskim |
| pubmed-article:10381171 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10381171 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:10381171 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10381171 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:10381171 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10381171 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10381171 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10381171 | pubmed:dateCreated | 1999-9-10 | lld:pubmed |
| pubmed-article:10381171 | pubmed:abstractText | In this study, we have investigated the ability of insulin-like growth factor I (IGF-I) to inhibit HIV long terminal repeat (LTR)-driven gene expression. Using COS 7 cells cotransfected with tat and an HIV LTR linked to a chloramphenicol acetyltransferase (CAT) reporter, we observed that physiological levels of IGF-I (10(-9) M) significantly inhibited CAT expression in a concentration- and time-dependent manner. IGF-I did not inhibit CAT expression in COS 7 cells transfected with pSVCAT, and did not affect CAT expression in the absence of cotransfection with tat. Transfection of HIV-1 proviral DNA into COS 7 cells +/- IGF-I resulted in a significant decrease (p < 0.05) in infectious virion production. Both IGF-I and Ro24-7429 inhibited LTR-driven CAT expression, while TNF-alpha-enhanced CAT expression was not affected by IGF-I. On the other hand, a plasmid encoding parathyroid hormone-related peptide exhibited dramatic additivity of inhibition of CAT expression in COS 7 cells. Finally, we show that in Jurkat or U937 cells cotransfected with HIVLTRCAT/tat, IGF-I significantly inhibited CAT expression. Further, interleukin 4 showed in U937 cells inhibition of CAT expression that was not additive to IGF-I induced inhibition. Our data demonstrate that IGF-I can specifically inhibit HIVLTRCAT expression. This inhibition may occur at the level of the tat/TAR interaction. Finally, this IGF-I effect is seen in target cell lines and similar paths of inhibition may be involved in the various cell types employed. | lld:pubmed |
| pubmed-article:10381171 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10381171 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10381171 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10381171 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10381171 | pubmed:issn | 0889-2229 | lld:pubmed |
| pubmed-article:10381171 | pubmed:author | pubmed-author:GerminarioR... | lld:pubmed |
| pubmed-article:10381171 | pubmed:author | pubmed-author:WainbergM AMA | lld:pubmed |
| pubmed-article:10381171 | pubmed:author | pubmed-author:Colby-Germina... | lld:pubmed |
| pubmed-article:10381171 | pubmed:author | pubmed-author:MaiHH | lld:pubmed |
| pubmed-article:10381171 | pubmed:author | pubmed-author:KleimanLL | lld:pubmed |
| pubmed-article:10381171 | pubmed:author | pubmed-author:DavisonKK | lld:pubmed |
| pubmed-article:10381171 | pubmed:author | pubmed-author:FaussDD | lld:pubmed |
| pubmed-article:10381171 | pubmed:author | pubmed-author:ChandonMM | lld:pubmed |
| pubmed-article:10381171 | pubmed:author | pubmed-author:AcelAA | lld:pubmed |
| pubmed-article:10381171 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10381171 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:10381171 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:10381171 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10381171 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10381171 | pubmed:pagination | 829-36 | lld:pubmed |
| pubmed-article:10381171 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10381171 | pubmed:meshHeading | pubmed-meshheading:10381171... | lld:pubmed |
| pubmed-article:10381171 | pubmed:meshHeading | pubmed-meshheading:10381171... | lld:pubmed |
| pubmed-article:10381171 | pubmed:meshHeading | pubmed-meshheading:10381171... | lld:pubmed |
| pubmed-article:10381171 | pubmed:meshHeading | pubmed-meshheading:10381171... | lld:pubmed |
| pubmed-article:10381171 | pubmed:meshHeading | pubmed-meshheading:10381171... | lld:pubmed |
| pubmed-article:10381171 | pubmed:meshHeading | pubmed-meshheading:10381171... | lld:pubmed |
| pubmed-article:10381171 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10381171 | pubmed:articleTitle | Effect of insulin-like growth factor I on HIV type 1 long terminal repeat-driven chloramphenicol acetyltransferase expression. | lld:pubmed |
| pubmed-article:10381171 | pubmed:affiliation | Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada. | lld:pubmed |
| pubmed-article:10381171 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10381171 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:10381171 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:10381171 | lld:entrezgene |
