| pubmed-article:10377991 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10377991 | lifeskim:mentions | umls-concept:C0040329 | lld:lifeskim |
| pubmed-article:10377991 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10377991 | lifeskim:mentions | umls-concept:C0243045 | lld:lifeskim |
| pubmed-article:10377991 | lifeskim:mentions | umls-concept:C0388730 | lld:lifeskim |
| pubmed-article:10377991 | lifeskim:mentions | umls-concept:C1332721 | lld:lifeskim |
| pubmed-article:10377991 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:10377991 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:10377991 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10377991 | pubmed:dateCreated | 1999-7-26 | lld:pubmed |
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| pubmed-article:10377991 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10377991 | pubmed:abstractText | The retinoblastoma (Rb) protein was originally identified as a product of a tumour suppressor gene that plays a pivotal role in regulating both the cell cycle and differentiation in mammals. The growth-suppressive activity of Rb is regulated by phosphorylation with cyclin-dependent kinase (CDK), and inactivation of the Rb function is one of the critical steps for transition from the G1 to the S phase. We report here the cloning of a cDNA (NtRb1) from Nicotiana tabacum which encodes a Rb-related protein, and show that this gene is expressed in all the organs examined at the mRNA level. We have demonstrated that NtRb1 interacts with tobacco cyclin D by using yeast two-hybrid and in vitro binding assays. In mammals, cyclin D can assemble with CDK4 and CDK6, but not with Cdc2, to form active complexes. Surprisingly, tobacco cyclin D and Cdc2 proteins can form a complex in insect cells, which is able to phosphorylate tobacco Rb-related protein in vitro. Using immunoprecipitation with the anti-cyclin D anti-body, cyclin D can be found in a complex with Cdc2 in suspension-cultured tobacco BY-2 cells. These results suggest that the cdc2 gene modulates the cell cycle through the phosphorylation of Rb-related protein by forming an active complex with cyclin D in plants. | lld:pubmed |
| pubmed-article:10377991 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10377991 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10377991 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10377991 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10377991 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10377991 | pubmed:month | May | lld:pubmed |
| pubmed-article:10377991 | pubmed:issn | 0960-7412 | lld:pubmed |
| pubmed-article:10377991 | pubmed:author | pubmed-author:ShinmyoAA | lld:pubmed |
| pubmed-article:10377991 | pubmed:author | pubmed-author:MurakamiHH | lld:pubmed |
| pubmed-article:10377991 | pubmed:author | pubmed-author:SekineMM | lld:pubmed |
| pubmed-article:10377991 | pubmed:author | pubmed-author:NakagamiHH | lld:pubmed |
| pubmed-article:10377991 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10377991 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:10377991 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10377991 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10377991 | pubmed:pagination | 243-52 | lld:pubmed |
| pubmed-article:10377991 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10377991 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10377991 | pubmed:articleTitle | Tobacco retinoblastoma-related protein phosphorylated by a distinct cyclin-dependent kinase complex with Cdc2/cyclin D in vitro. | lld:pubmed |
| pubmed-article:10377991 | pubmed:affiliation | Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), Japan. | lld:pubmed |
| pubmed-article:10377991 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10377991 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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