| pubmed-article:10373466 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10373466 | lifeskim:mentions | umls-concept:C0029246 | lld:lifeskim |
| pubmed-article:10373466 | lifeskim:mentions | umls-concept:C0016163 | lld:lifeskim |
| pubmed-article:10373466 | lifeskim:mentions | umls-concept:C0599044 | lld:lifeskim |
| pubmed-article:10373466 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10373466 | lifeskim:mentions | umls-concept:C0700114 | lld:lifeskim |
| pubmed-article:10373466 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10373466 | lifeskim:mentions | umls-concept:C1097411 | lld:lifeskim |
| pubmed-article:10373466 | lifeskim:mentions | umls-concept:C1879647 | lld:lifeskim |
| pubmed-article:10373466 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:10373466 | lifeskim:mentions | umls-concept:C0075804 | lld:lifeskim |
| pubmed-article:10373466 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:10373466 | pubmed:dateCreated | 1999-7-15 | lld:pubmed |
| pubmed-article:10373466 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10373466 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10373466 | pubmed:abstractText | We determined the complete nucleotide sequences of the alpha1 subunit gene (OlGCS-alpha1) and the beta1 subunit gene (OlGCS-beta1) of medaka fish soluble guanylyl cyclase. In the genome, OlGCS-alpha1 and OlGCS-beta1 are organized in tandem. The two genes are only 986 base pairs apart and span approximately 34 kilobase pairs in the order of OlGCS-alpha1 and OlGCS-beta1. The nucleotide sequence of a large part of the 5'-upstream region of OlGCS-alpha1 is complimentarily conserved in that of OlGCS-beta1. To analyze the promoter activity of each gene, a fusion gene construct in which the 5'-upstream region was fused with the green fluorescent protein gene was injected into medaka fish 2-cell embryos. When the fusion gene containing the OlGCS-alpha1 upstream region was injected, green fluorescent protein fluorescence was detected in the embryonic brain. The 5'-upstream region of OlGCS-beta1 alone was insufficient for the reporter gene expression in the embryos. When the OlGCS-alpha1 upstream region was located upstream of the OlGCS-beta1-green fluorescence protein fusion gene, the reporter gene was expressed in the brain and trunk region of the embryos. These results suggest that the 5'-upstream region of OlGCS-alpha1 can affect the expression of OlGCS-beta1. It is therefore possible that the expression of OlGCS-alpha1 and OlGCS-beta1 is coordinated. | lld:pubmed |
| pubmed-article:10373466 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10373466 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10373466 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10373466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10373466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10373466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10373466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10373466 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10373466 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10373466 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10373466 | pubmed:author | pubmed-author:MikamiTT | lld:pubmed |
| pubmed-article:10373466 | pubmed:author | pubmed-author:SuzukiNN | lld:pubmed |
| pubmed-article:10373466 | pubmed:author | pubmed-author:KusakabeTT | lld:pubmed |
| pubmed-article:10373466 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10373466 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:10373466 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10373466 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10373466 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10373466 | pubmed:pagination | 18567-73 | lld:pubmed |
| pubmed-article:10373466 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10373466 | pubmed:meshHeading | pubmed-meshheading:10373466... | lld:pubmed |
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| pubmed-article:10373466 | pubmed:meshHeading | pubmed-meshheading:10373466... | lld:pubmed |
| pubmed-article:10373466 | pubmed:meshHeading | pubmed-meshheading:10373466... | lld:pubmed |
| pubmed-article:10373466 | pubmed:meshHeading | pubmed-meshheading:10373466... | lld:pubmed |
| pubmed-article:10373466 | pubmed:meshHeading | pubmed-meshheading:10373466... | lld:pubmed |
| pubmed-article:10373466 | pubmed:meshHeading | pubmed-meshheading:10373466... | lld:pubmed |
| pubmed-article:10373466 | pubmed:meshHeading | pubmed-meshheading:10373466... | lld:pubmed |
| pubmed-article:10373466 | pubmed:meshHeading | pubmed-meshheading:10373466... | lld:pubmed |
| pubmed-article:10373466 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10373466 | pubmed:articleTitle | Tandem organization of medaka fish soluble guanylyl cyclase alpha1 and beta1 subunit genes. Implications for coordinated transcription of two subunit genes. | lld:pubmed |
| pubmed-article:10373466 | pubmed:affiliation | Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan. | lld:pubmed |
| pubmed-article:10373466 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10373466 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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