| pubmed-article:10368637 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10368637 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10368637 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:10368637 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:10368637 | lifeskim:mentions | umls-concept:C0205281 | lld:lifeskim |
| pubmed-article:10368637 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:10368637 | pubmed:issue | 2A | lld:pubmed |
| pubmed-article:10368637 | pubmed:dateCreated | 1999-7-1 | lld:pubmed |
| pubmed-article:10368637 | pubmed:abstractText | Glioblastoma is the most invasive form of primary brain tumors, and is often refractory to chemotherapy. Herein, we provide evidence that two highly invasive human glioma cell lines U-87 MG and U-373 MG, entered apoptosis after 48 hours following 24 h growth arrest induced by Doxorubicin (10 micrograms/2 x 10(5) cells/ml). Apoptosis depended solely on the level of intracellular drug accumulation, and it was not related to a functional p53 tumor suppressor factor. The multidrug resistance gene 1 (mdr-1) encoded P-glycoprotein (P-gp) was weakly expressed in these cells upon exposure to Doxorubicin, and exerted no influence on the extent of cellular drug efflux. Drug efflux occurred only in U-373 MG glioma cells subsequent to physical damage of the membrane upon exposure to Doxorubicin. Pretreatment of tumor cells with 10 micrograms/ml Doxorubicin precluded tumor formation on the chorioallantoic membrane (CAM) of embryonated hen eggs. Single-dose application of 0.4 microgram Doxorubicin on CAM/U-87 MG and CAM/U-373 MG tumor transplants inhibited tumor invasion in CAM tissue by 40 to 50%. These data suggest that highly invasive glioblastomas can be driven to apoptosis following growth arrest induced by Doxorubicin, providing that intracellular drug accumulation suffices cytotoxic levels. | lld:pubmed |
| pubmed-article:10368637 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10368637 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10368637 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10368637 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10368637 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10368637 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10368637 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10368637 | pubmed:issn | 0250-7005 | lld:pubmed |
| pubmed-article:10368637 | pubmed:author | pubmed-author:WalterG FGF | lld:pubmed |
| pubmed-article:10368637 | pubmed:author | pubmed-author:RaduDD | lld:pubmed |
| pubmed-article:10368637 | pubmed:author | pubmed-author:CasaresSS | lld:pubmed |
| pubmed-article:10368637 | pubmed:author | pubmed-author:BrumeanuT DTD | lld:pubmed |
| pubmed-article:10368637 | pubmed:author | pubmed-author:StanA CAC | lld:pubmed |
| pubmed-article:10368637 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10368637 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10368637 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10368637 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10368637 | pubmed:pagination | 941-50 | lld:pubmed |
| pubmed-article:10368637 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10368637 | pubmed:meshHeading | pubmed-meshheading:10368637... | lld:pubmed |
| pubmed-article:10368637 | pubmed:meshHeading | pubmed-meshheading:10368637... | lld:pubmed |
| pubmed-article:10368637 | pubmed:meshHeading | pubmed-meshheading:10368637... | lld:pubmed |
| pubmed-article:10368637 | pubmed:meshHeading | pubmed-meshheading:10368637... | lld:pubmed |
| pubmed-article:10368637 | pubmed:meshHeading | pubmed-meshheading:10368637... | lld:pubmed |
| pubmed-article:10368637 | pubmed:meshHeading | pubmed-meshheading:10368637... | lld:pubmed |
| pubmed-article:10368637 | pubmed:meshHeading | pubmed-meshheading:10368637... | lld:pubmed |
| pubmed-article:10368637 | pubmed:meshHeading | pubmed-meshheading:10368637... | lld:pubmed |
| pubmed-article:10368637 | pubmed:articleTitle | Doxorubicin-induced cell death in highly invasive human gliomas. | lld:pubmed |
| pubmed-article:10368637 | pubmed:affiliation | Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. | lld:pubmed |
| pubmed-article:10368637 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10368637 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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