| pubmed-article:10367890 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10367890 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:10367890 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10367890 | lifeskim:mentions | umls-concept:C0085187 | lld:lifeskim |
| pubmed-article:10367890 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10367890 | pubmed:dateCreated | 1999-6-29 | lld:pubmed |
| pubmed-article:10367890 | pubmed:abstractText | The yeast Sir2/3/4p complex is found in abundance at telomeres, where it participates in the formation of silent heterochromatin and telomere maintenance. Here, we show that Sir3p is released from telomeres in response to DNA double-strand breaks (DSBs), binds to DSBs, and mediates their repair, independent of cell mating type. Sir3p relocalization is S phase specific and, importantly, requires the DNA damage checkpoint genes MEC1 and RAD9. MEC1 is a homolog of ATM, mutations in which cause ataxia telangiectasia (A-T), a disease characterized by various neurologic and immunologic abnormalities, a predisposition for cancer, and a cellular defect in repair of DSBs. This novel mode by which preformed DNA repair machinery is mobilized by DNA damage sensors may have implications for human diseases resulting from defective DSB repair. | lld:pubmed |
| pubmed-article:10367890 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10367890 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10367890 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10367890 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10367890 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10367890 | pubmed:month | May | lld:pubmed |
| pubmed-article:10367890 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:10367890 | pubmed:author | pubmed-author:GuarenteLL | lld:pubmed |
| pubmed-article:10367890 | pubmed:author | pubmed-author:SinclairD ADA | lld:pubmed |
| pubmed-article:10367890 | pubmed:author | pubmed-author:MillsK DKD | lld:pubmed |
| pubmed-article:10367890 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10367890 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:10367890 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:10367890 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10367890 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10367890 | pubmed:pagination | 609-20 | lld:pubmed |
| pubmed-article:10367890 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:10367890 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10367890 | pubmed:articleTitle | MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. | lld:pubmed |
| pubmed-article:10367890 | pubmed:affiliation | Massachusetts Institute of Technology, Department of Biology, Cambridge 02139, USA. | lld:pubmed |
| pubmed-article:10367890 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10367890 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10367890 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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