| pubmed-article:10367565 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10367565 | lifeskim:mentions | umls-concept:C0242643 | lld:lifeskim |
| pubmed-article:10367565 | lifeskim:mentions | umls-concept:C1512977 | lld:lifeskim |
| pubmed-article:10367565 | lifeskim:mentions | umls-concept:C0242640 | lld:lifeskim |
| pubmed-article:10367565 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:10367565 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:10367565 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10367565 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:10367565 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10367565 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10367565 | pubmed:dateCreated | 1999-7-30 | lld:pubmed |
| pubmed-article:10367565 | pubmed:abstractText | In the previous study we have found that Djungarian hamster fibroblasts with high levels of multidrug resistance (MDR) (colchicine-resistance index RI of 1000 to 42000) produce soluble factor(s) communicating MDR to the drug-sensitive cells of the same species by elevating the functional activity of P-glycoprotein (Pgp). Here we have shown that these cells can influence human tumor cells in the same fashion. Rat hepatoma McA RH7777 cells and their colchicine-resistant derivatives are shown to produce a factor with similar effects (induction of MDR and Pgp functional activity in the drug-sensitive cells). These effects seem to depend on the drug resistance level of the donor cells. Our results show that induction of the Pgp-mediated MDR is not species-specific and the tumor cells with intrinsic MDR (arising from the tissue with a high level of Pgp expression) can produce a factor(s) communicating this type of drug resistance to the sensitive cells. | lld:pubmed |
| pubmed-article:10367565 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10367565 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10367565 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10367565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10367565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10367565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10367565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10367565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10367565 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10367565 | pubmed:issn | 1023-6597 | lld:pubmed |
| pubmed-article:10367565 | pubmed:author | pubmed-author:StavrovskayaA... | lld:pubmed |
| pubmed-article:10367565 | pubmed:author | pubmed-author:KakpakovaE... | lld:pubmed |
| pubmed-article:10367565 | pubmed:author | pubmed-author:SidorovaT ATA | lld:pubmed |
| pubmed-article:10367565 | pubmed:author | pubmed-author:EliseenkovaA... | lld:pubmed |
| pubmed-article:10367565 | pubmed:author | pubmed-author:KtitorovaO... | lld:pubmed |
| pubmed-article:10367565 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10367565 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:10367565 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10367565 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10367565 | pubmed:pagination | 469-79 | lld:pubmed |
| pubmed-article:10367565 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:meshHeading | pubmed-meshheading:10367565... | lld:pubmed |
| pubmed-article:10367565 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:10367565 | pubmed:articleTitle | Induction of P-glycoprotein functional activity and multidrug resistance by a soluble factor(s) produced by some mammalian cells. | lld:pubmed |
| pubmed-article:10367565 | pubmed:affiliation | Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow. | lld:pubmed |
| pubmed-article:10367565 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10367565 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
