| pubmed-article:10364179 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C0026237 | lld:lifeskim |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C0010656 | lld:lifeskim |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C0010749 | lld:lifeskim |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:10364179 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:10364179 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:10364179 | pubmed:dateCreated | 1999-7-15 | lld:pubmed |
| pubmed-article:10364179 | pubmed:abstractText | We investigated the ability of caspases (cysteine proteases with aspartic acid specificity) to induce cytochrome c release from mitochondria. When Jurkat cells were induced to undergo apoptosis by Fas receptor ligation, cytochrome c was released from mitochondria, an event that was prevented by the caspase inhibitor, zVAD-fmk (zVal-Ala-Asp-CH2F). Purified caspase-8 triggered rapid cytochrome c release from isolated mitochondria in vitro. The effect was indirect, as the presence of cytosol was required, suggesting that caspase-8 cleaves and activates a cytosolic substrate, which in turn is able to induce cytochrome c release from mitochondria. The cytochrome c releasing activity was not blocked by caspase inhibition, but was antagonized by Bcl-2 or Bcl-xL. Caspase-8 and caspase-3 cleaved Bid, a proapoptotic Bcl-2 family member, which gains cytochrome c releasing activity in response to caspase cleavage. However, caspase-6 and caspase-7 did not cleave Bid, although they initiated cytochrome c release from mitochondria in the presence of cytosol. Thus, effector caspases may cleave and activate another cytosolic substrate (other than Bid), which then promotes cytochrome c release from mitochondria. Mitochondria significantly amplified the caspase-8 initiated DEVD-specific cleavage activity. Our data suggest that cytochrome c release, initiated by the action of caspases on a cytosolic substrates, may act to amplify a caspase cascade during apoptosis. | lld:pubmed |
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| pubmed-article:10364179 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10364179 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10364179 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10364179 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10364179 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10364179 | pubmed:author | pubmed-author:GreenD RDR | lld:pubmed |
| pubmed-article:10364179 | pubmed:author | pubmed-author:Bossy-WetzelE... | lld:pubmed |
| pubmed-article:10364179 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10364179 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:10364179 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10364179 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10364179 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10364179 | pubmed:pagination | 17484-90 | lld:pubmed |
| pubmed-article:10364179 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10364179 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10364179 | pubmed:articleTitle | Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. | lld:pubmed |
| pubmed-article:10364179 | pubmed:affiliation | Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA. | lld:pubmed |
| pubmed-article:10364179 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10364179 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10364179 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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