Linked Life Data

10362111

Source:http://linkedlifedata.com/resource/pubmed/id/10362111

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10362111rdf:typepubmed:Citationlld:pubmed
pubmed-article:10362111lifeskim:mentionsumls-concept:C0149925lld:lifeskim
pubmed-article:10362111lifeskim:mentionsumls-concept:C0162638lld:lifeskim
pubmed-article:10362111lifeskim:mentionsumls-concept:C0334227lld:lifeskim
pubmed-article:10362111lifeskim:mentionsumls-concept:C1367731lld:lifeskim
pubmed-article:10362111lifeskim:mentionsumls-concept:C1150587lld:lifeskim
pubmed-article:10362111lifeskim:mentionsumls-concept:C1705632lld:lifeskim
pubmed-article:10362111lifeskim:mentionsumls-concept:C1515877lld:lifeskim
pubmed-article:10362111lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:10362111lifeskim:mentionsumls-concept:C1879547lld:lifeskim
pubmed-article:10362111lifeskim:mentionsumls-concept:C0441712lld:lifeskim
pubmed-article:10362111lifeskim:mentionsumls-concept:C0075400lld:lifeskim
pubmed-article:10362111pubmed:issue7lld:pubmed
pubmed-article:10362111pubmed:dateCreated1999-6-24lld:pubmed
pubmed-article:10362111pubmed:abstractText[Arg6,D-Trp7,9,NmePhe8]-substance P (6-11) (antagonist G) is a novel class of anti-cancer agent that inhibits small-cell lung cancer (SCLC) cell growth in vitro and in vivo and is entering phase II clinical investigation for the treatment of SCLC. Although antagonist G blocks SCLC cell growth (IC50 = 24.5 +/- 1.5 and 38.5 +/- 1.5 microM for the H69 and H510 cell lines respectively), its exact mechanism of action is unclear. This study shows that antagonist G stimulates apoptosis as assessed by morphology (EC50 = 5.9 +/- 0.1 and 15.2 +/- 2.7 microM for the H69 and H510 cell lines respectively) and stimulates c-jun-N-terminal kinase (JNK) activity in SCLC cells (EC50 = 3.2 +/- 0.1 and 15.2 +/- 2.7 microM). This activity is neuropeptide-independent, but dependent on the generation of reactive oxygen species (ROS) and is inhibited by the free radical scavenger n-acetyl cysteine. Furthermore, antagonist G itself induces inflammation (59% increase in oedema volume compared to control) and potentiates (by 35-40%) bradykinin-induced oedema formation in vivo. In view of these results we show that, as well as acting as a 'broad-spectrum' neuropeptide antagonist, antagonist G stimulates basal G-protein activity in SCLC cell membranes (81 +/- 12% stimulation at 10 microM), thereby displaying a unique ability to stimulate certain signal transduction pathways by activating G-proteins. This novel activity may be instrumental for full anti-cancer activity in SCLC cells and may also account for antagonist G activity in non-neuropeptide-dependent cancers.lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:languageenglld:pubmed
pubmed-article:10362111pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:citationSubsetIMlld:pubmed
pubmed-article:10362111pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10362111pubmed:statusMEDLINElld:pubmed
pubmed-article:10362111pubmed:monthJunlld:pubmed
pubmed-article:10362111pubmed:issn0007-0920lld:pubmed
pubmed-article:10362111pubmed:authorpubmed-author:SmythJ FJFlld:pubmed
pubmed-article:10362111pubmed:authorpubmed-author:ArmstrongR...lld:pubmed
pubmed-article:10362111pubmed:authorpubmed-author:CummingsJJlld:pubmed
pubmed-article:10362111pubmed:authorpubmed-author:HaslettCClld:pubmed
pubmed-article:10362111pubmed:authorpubmed-author:WatersC MCMlld:pubmed
pubmed-article:10362111pubmed:authorpubmed-author:SethiTTlld:pubmed
pubmed-article:10362111pubmed:authorpubmed-author:MacKinnonA...lld:pubmed
pubmed-article:10362111pubmed:issnTypePrintlld:pubmed
pubmed-article:10362111pubmed:volume80lld:pubmed
pubmed-article:10362111pubmed:ownerNLMlld:pubmed
pubmed-article:10362111pubmed:authorsCompleteYlld:pubmed
pubmed-article:10362111pubmed:pagination1026-34lld:pubmed
pubmed-article:10362111pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
pubmed-article:10362111pubmed:meshHeadingpubmed-meshheading:10362111...lld:pubmed
More...