| pubmed-article:10362108 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10362108 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:10362108 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:10362108 | lifeskim:mentions | umls-concept:C0947647 | lld:lifeskim |
| pubmed-article:10362108 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:10362108 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:10362108 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10362108 | pubmed:dateCreated | 1999-6-24 | lld:pubmed |
| pubmed-article:10362108 | pubmed:abstractText | The extracellular (interstitial) pH (pHe) of solid tumours is significantly more acidic compared to normal tissues. In-vitro, low pH reduces the uptake of weakly basic chemotherapeutic drugs and, hence, reduces their cytotoxicity. This phenomenon has been postulated to contribute to a 'physiological' resistance to weakly basic drugs in vivo. Doxorubicin is a weak base chemotherapeutic agent that is commonly used in combination chemotherapy to clinically treat breast cancers. This report demonstrates that MCF-7 human breast cancer cells in vitro are more susceptible to doxorubicin toxicity at pH 7.4, compared to pH 6.8. Furthermore 31P-magnetic resonance spectroscopy (MRS) has shown that the pHe of MCF-7 human breast cancer xenografts can be effectively and significantly raised with sodium bicarbonate in drinking water. The bicarbonate-induced extracellular alkalinization leads to significant improvements in the therapeutic effectiveness of doxorubicin against MCF-7 xenografts in vivo. Although physiological resistance to weakly basic chemotherapeutics is well-documented in vitro and in theory, these data represent the first in vivo demonstration of this important phenomenon. | lld:pubmed |
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| pubmed-article:10362108 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10362108 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10362108 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10362108 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10362108 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10362108 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10362108 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10362108 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:10362108 | pubmed:author | pubmed-author:RoyPP | lld:pubmed |
| pubmed-article:10362108 | pubmed:author | pubmed-author:GilliesR JRJ | lld:pubmed |
| pubmed-article:10362108 | pubmed:author | pubmed-author:TaylorC WCW | lld:pubmed |
| pubmed-article:10362108 | pubmed:author | pubmed-author:BaggettBB | lld:pubmed |
| pubmed-article:10362108 | pubmed:author | pubmed-author:HUHH | lld:pubmed |
| pubmed-article:10362108 | pubmed:author | pubmed-author:BhujwallaZ... | lld:pubmed |
| pubmed-article:10362108 | pubmed:author | pubmed-author:RaghunandNN | lld:pubmed |
| pubmed-article:10362108 | pubmed:author | pubmed-author:MahoneyBB | lld:pubmed |
| pubmed-article:10362108 | pubmed:author | pubmed-author:van SluisRR | lld:pubmed |
| pubmed-article:10362108 | pubmed:author | pubmed-author:Paine-Murriet... | lld:pubmed |
| pubmed-article:10362108 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10362108 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:10362108 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10362108 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10362108 | pubmed:pagination | 1005-11 | lld:pubmed |
| pubmed-article:10362108 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10362108 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10362108 | pubmed:articleTitle | Enhancement of chemotherapy by manipulation of tumour pH. | lld:pubmed |
| pubmed-article:10362108 | pubmed:affiliation | Arizona Cancer Center, Tucson 85724-5024, USA. | lld:pubmed |
| pubmed-article:10362108 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10362108 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10362108 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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