| pubmed-article:10360647 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C1335960 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C0677626 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C0033374 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C0805732 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C1366753 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C1415793 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C0031669 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C0205548 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C0142812 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C1548425 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10360647 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10360647 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:10360647 | pubmed:dateCreated | 1999-6-23 | lld:pubmed |
| pubmed-article:10360647 | pubmed:abstractText | Although interferon-alpha (IFN-alpha) has shown great promise in the treatment of chronic viral hepatitis, the anti-tumour effect of this agent in the therapy of liver cancer is unclear. Recent studies have demonstrated that differentiation-inducing agents could modulate the responsiveness of cancer cells to IFN-alpha by regulating the expression of signal transducers and activators of transcription (STAT) proteins, a group of transcription factors which play important roles in the IFN signalling pathway. We have reported that sodium butyrate is a potent differentiation inducer for human hepatoma cells. In this study, we investigated whether this drug could regulate the expression of STAT proteins and enhance the anti-tumour effect of IFN-alpha in hepatoma cells. We found that sodium butyrate specifically activated STAT1 gene expression and enhanced IFN-alpha-induced phosphorylation and activation of STAT1 proteins. Co-treatment with these two drugs led to G1 growth arrest, accompanied by down-regulation of cyclin D1 and up-regulation of p21WAF-1, and accumulation of hypophosphorylated retinoblastoma protein in hepatoma cells. Additionally, internucleosomal DNA fragmentation, a biological hallmark of apoptosis, was detected in hepatoma cells after continuous incubation with a combination of these two drugs for 72 h. Our results show that sodium butyrate potently enhances the anti-tumour effect of IFN-alpha in vitro and suggest that a rational combination of these two drugs may be useful for the treatment of liver cancer. | lld:pubmed |
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| pubmed-article:10360647 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10360647 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10360647 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10360647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10360647 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10360647 | pubmed:month | May | lld:pubmed |
| pubmed-article:10360647 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:10360647 | pubmed:author | pubmed-author:ChuangL YLY | lld:pubmed |
| pubmed-article:10360647 | pubmed:author | pubmed-author:HungW CWC | lld:pubmed |
| pubmed-article:10360647 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10360647 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:10360647 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10360647 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10360647 | pubmed:pagination | 705-10 | lld:pubmed |
| pubmed-article:10360647 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:10360647 | pubmed:meshHeading | pubmed-meshheading:10360647... | lld:pubmed |
| pubmed-article:10360647 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10360647 | pubmed:articleTitle | Sodium butyrate enhances STAT 1 expression in PLC/PRF/5 hepatoma cells and augments their responsiveness to interferon-alpha. | lld:pubmed |
| pubmed-article:10360647 | pubmed:affiliation | School of Technology for Medical Sciences, Kaohsiung Medical College, Taiwan, Republic of China. | lld:pubmed |
| pubmed-article:10360647 | pubmed:publicationType | Journal Article | lld:pubmed |
