| pubmed-article:10359836 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10359836 | lifeskim:mentions | umls-concept:C0299583 | lld:lifeskim |
| pubmed-article:10359836 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:10359836 | lifeskim:mentions | umls-concept:C0005903 | lld:lifeskim |
| pubmed-article:10359836 | lifeskim:mentions | umls-concept:C0013470 | lld:lifeskim |
| pubmed-article:10359836 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:10359836 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:10359836 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10359836 | pubmed:dateCreated | 1999-7-8 | lld:pubmed |
| pubmed-article:10359836 | pubmed:abstractText | Leptin regulates energy balance through its actions in the brain on appetite and energy expenditure and also shares properties with cytokines such as IL-1. We report here that leptin, injected into rats intracerebroventricularly or peripherally, induces significant dose-dependent increases in core body temperature as well as suppression of appetite. Leptin failed to affect food intake or body temperature in obese (fa/fa) Zucker rats, which posses a defective leptin receptor. Furthermore, injection of leptin increased levels of the proinflammatory cytokine IL-1beta in the hypothalamus of normal Sprague-Dawley rats. Central injection of IL-1 receptor antagonist (IL-1ra) inhibited the suppression of food intake caused by central or peripheral injection of leptin (60 and 84%, respectively) and abolished the leptin-induced increase in body temperature in both cases. Mice lacking (gene knockout) the main IL-1 receptor (80 kDa, R1) responsible for IL-1 actions showed no reduction in food intake in response to leptin. These data indicate that leptin actions in the brain depend on IL-1, and we show further that the effect of leptin on fever, but not food intake, is abolished by a cyclooxygenase inhibitor. Thus, we propose that in addition to its role in body weight regulation, leptin may mediate neuroimmune responses via actions in the brain dependent on release of IL-1 and prostaglandins. | lld:pubmed |
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| pubmed-article:10359836 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10359836 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10359836 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10359836 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10359836 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10359836 | pubmed:author | pubmed-author:GardnerJ DJD | lld:pubmed |
| pubmed-article:10359836 | pubmed:author | pubmed-author:RothwellN JNJ | lld:pubmed |
| pubmed-article:10359836 | pubmed:author | pubmed-author:LuheshiG NGN | lld:pubmed |
| pubmed-article:10359836 | pubmed:author | pubmed-author:LoudonA SAS | lld:pubmed |
| pubmed-article:10359836 | pubmed:author | pubmed-author:RushforthD... | lld:pubmed |
| pubmed-article:10359836 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10359836 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:10359836 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10359836 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10359836 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10359836 | pubmed:pagination | 7047-52 | lld:pubmed |
| pubmed-article:10359836 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10359836 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10359836 | pubmed:articleTitle | Leptin actions on food intake and body temperature are mediated by IL-1. | lld:pubmed |
| pubmed-article:10359836 | pubmed:affiliation | School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom. | lld:pubmed |
| pubmed-article:10359836 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10359836 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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