| pubmed-article:10359762 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10359762 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10359762 | lifeskim:mentions | umls-concept:C0080129 | lld:lifeskim |
| pubmed-article:10359762 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10359762 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10359762 | lifeskim:mentions | umls-concept:C1150423 | lld:lifeskim |
| pubmed-article:10359762 | lifeskim:mentions | umls-concept:C0282116 | lld:lifeskim |
| pubmed-article:10359762 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10359762 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10359762 | pubmed:dateCreated | 1999-7-8 | lld:pubmed |
| pubmed-article:10359762 | pubmed:abstractText | A considerable body of evidence points to a role for both cyclin E/cyclin-dependent kinase (cdk)2 activity and E2F transcription activity in the induction of S phase. We show that overexpression of cyclin E/cdk2 in quiescent cells induces S phase, that this coincides with an induction of E2F activity, and that coexpression of E2F enhances the cyclin E/cdk2-mediated induction of S phase. Likewise, E2F overexpression can induce S phase and does so in the apparent absence of cyclin E/cdk2 activity. In addition, although the inhibition of cyclin E/cdk2 activity blocks the induction of S phase after growth stimulation of normal mouse embryo fibroblasts, inhibition of cyclin E/cdk2 does not block S phase induction in Rb-/- cells where E2F activity is deregulated. These results point to the important roles for E2F and cyclin E/cdk2 in the induction of S phase. Moreover, the nature of the E2F targets and the suspected targets for cyclin E/cdk2 suggests a potential molecular mechanism for the collaborative action of cyclin E/cdk2 and E2F in the induction of S phase. | lld:pubmed |
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| pubmed-article:10359762 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10359762 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10359762 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10359762 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10359762 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10359762 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10359762 | pubmed:author | pubmed-author:JakoiLL | lld:pubmed |
| pubmed-article:10359762 | pubmed:author | pubmed-author:LeoneGG | lld:pubmed |
| pubmed-article:10359762 | pubmed:author | pubmed-author:NevinsJ RJR | lld:pubmed |
| pubmed-article:10359762 | pubmed:author | pubmed-author:DeGregoriJJ | lld:pubmed |
| pubmed-article:10359762 | pubmed:author | pubmed-author:CookJ GJG | lld:pubmed |
| pubmed-article:10359762 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10359762 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:10359762 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10359762 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10359762 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10359762 | pubmed:pagination | 6626-31 | lld:pubmed |
| pubmed-article:10359762 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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