pubmed-article:10359702 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10359702 | lifeskim:mentions | umls-concept:C0541150 | lld:lifeskim |
pubmed-article:10359702 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
pubmed-article:10359702 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
pubmed-article:10359702 | pubmed:issue | 11 | lld:pubmed |
pubmed-article:10359702 | pubmed:dateCreated | 1999-7-20 | lld:pubmed |
pubmed-article:10359702 | pubmed:abstractText | The serine/threonine kinase Akt (also known as protein kinase B, PKB) is activated by numerous growth-factor and immune receptors through lipid products of phosphatidylinositol (PI) 3-kinase. Akt can couple to pathways that regulate glucose metabolism or cell survival [1]. Akt can also regulate several transcription factors, including E2F, CREB, and the Forkhead family member Daf-16 [2] [3] [4]. Here, we show that Akt can regulate signaling pathways that lead to induction of the NF-kappaB family of transcription factors in the Jurkat T-cell line. This induction occurs, at least in part, at the level of degradation of the NF-kappaB inhibitor IkappaB, and is specific for NF-kappaB, as other inducible transcription factors are not affected by Akt overexpression. Furthermore, the effect requires the kinase activity and pleckstrin homology (PH) domain of Akt. Also, Akt does not act alone to induce cytokine promoters and NF-kappaB reporters, because signals from other pathways are required to observe the effect. These studies uncover a previously unappreciated connection between Akt and NF-kappaB induction that could have implications for the control of T-cell growth and survival. | lld:pubmed |
pubmed-article:10359702 | pubmed:language | eng | lld:pubmed |
pubmed-article:10359702 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10359702 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10359702 | pubmed:month | Jun | lld:pubmed |
pubmed-article:10359702 | pubmed:issn | 0960-9822 | lld:pubmed |
pubmed-article:10359702 | pubmed:author | pubmed-author:WeiseWW | lld:pubmed |
pubmed-article:10359702 | pubmed:author | pubmed-author:StokoeDD | lld:pubmed |
pubmed-article:10359702 | pubmed:author | pubmed-author:LIENI NIN | lld:pubmed |
pubmed-article:10359702 | pubmed:author | pubmed-author:ShapiroV SVS | lld:pubmed |
pubmed-article:10359702 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10359702 | pubmed:day | 3 | lld:pubmed |
pubmed-article:10359702 | pubmed:volume | 9 | lld:pubmed |
pubmed-article:10359702 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10359702 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10359702 | pubmed:pagination | 601-4 | lld:pubmed |
pubmed-article:10359702 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:meshHeading | pubmed-meshheading:10359702... | lld:pubmed |
pubmed-article:10359702 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:10359702 | pubmed:articleTitle | Induction of NF-kappaB by the Akt/PKB kinase. | lld:pubmed |
pubmed-article:10359702 | pubmed:affiliation | Department of Medicine, University of California, San Francisco, California 94143, USA. | lld:pubmed |
pubmed-article:10359702 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10359702 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:10359702 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10359702 | lld:pubmed |