pubmed-article:10358769 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10358769 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
pubmed-article:10358769 | lifeskim:mentions | umls-concept:C0031308 | lld:lifeskim |
pubmed-article:10358769 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
pubmed-article:10358769 | pubmed:dateCreated | 1999-8-31 | lld:pubmed |
pubmed-article:10358769 | pubmed:abstractText | Phagocytosis of pathogens by macrophages initiates the innate immune response, which in turn orchestrates the adaptive response. In order to discriminate between infectious agents and self, macrophages have evolved a restricted number of phagocytic receptors, like the mannose receptor, that recognize conserved motifs on pathogens. Pathogens are also phagocytosed by complement receptors after relatively nonspecific opsonization with complement and by Fc receptors after specific opsonization with antibodies. All these receptors induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle. However, important differences in the molecular mechanisms underlying phagocytosis by different receptors are now being appreciated. These include differences in the cytoskeletal elements that mediate ingestion, differences in vacuole maturation, and differences in inflammatory responses. Infectious agents, such as M. tuberculosis, Legionella pneumophila, and Salmonella typhimurium, enter macrophages via heterogeneous pathways and modify vacuolar maturation in a manner that favors their survival. Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response. | lld:pubmed |
pubmed-article:10358769 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10358769 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10358769 | pubmed:language | eng | lld:pubmed |
pubmed-article:10358769 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10358769 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:10358769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10358769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10358769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10358769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10358769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10358769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10358769 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10358769 | pubmed:issn | 0732-0582 | lld:pubmed |
pubmed-article:10358769 | pubmed:author | pubmed-author:UnderhillD... | lld:pubmed |
pubmed-article:10358769 | pubmed:author | pubmed-author:AderemAA | lld:pubmed |
pubmed-article:10358769 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10358769 | pubmed:volume | 17 | lld:pubmed |
pubmed-article:10358769 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10358769 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10358769 | pubmed:pagination | 593-623 | lld:pubmed |
pubmed-article:10358769 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:meshHeading | pubmed-meshheading:10358769... | lld:pubmed |
pubmed-article:10358769 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:10358769 | pubmed:articleTitle | Mechanisms of phagocytosis in macrophages. | lld:pubmed |
pubmed-article:10358769 | pubmed:affiliation | Department of Immunology, University of Washington, Seattle 98195, USA. aaderem@u.washington.edu | lld:pubmed |
pubmed-article:10358769 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10358769 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:10358769 | pubmed:publicationType | Review | lld:pubmed |
pubmed-article:10358769 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358769 | lld:pubmed |