| pubmed-article:10358044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10358044 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:10358044 | lifeskim:mentions | umls-concept:C0140145 | lld:lifeskim |
| pubmed-article:10358044 | lifeskim:mentions | umls-concept:C0018873 | lld:lifeskim |
| pubmed-article:10358044 | lifeskim:mentions | umls-concept:C1257739 | lld:lifeskim |
| pubmed-article:10358044 | lifeskim:mentions | umls-concept:C0282498 | lld:lifeskim |
| pubmed-article:10358044 | lifeskim:mentions | umls-concept:C0030012 | lld:lifeskim |
| pubmed-article:10358044 | lifeskim:mentions | umls-concept:C1332102 | lld:lifeskim |
| pubmed-article:10358044 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:10358044 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10358044 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:10358044 | pubmed:dateCreated | 1999-7-6 | lld:pubmed |
| pubmed-article:10358044 | pubmed:abstractText | The early response genes, c-Fos and c-Jun, are induced by environmental stress and are thought to modulate injury processes via the induction of AP-1-dependent target genes. AP-1 activation is thought to be regulated by changes in intracellular oxidation/reduction reactions involving the redox factor-1 (Ref-1) protein. In this study, NIH 3T3 and HeLa cells were used to determine whether heat shock induces the AP-1 transcription factor via signaling pathways involving Ref-1. Reverse transcriptase-polymerase chain reaction analysis and immunoblotting demonstrated that c-Fos and c-Jun were induced 2-10 h following heat shock, and this induction was accompanied by an increase in AP-1 DNA binding. Electrophoretic mobility shift assay extracts immunodepleted of Ref-1 protein demonstrated that the increase in AP-1 DNA-binding activity following heating was dependent upon the presence of Ref-1 and that Ref-1 regulates inducible, but not basal, AP-1 DNA-binding activity. This was confirmed by the restoration of heat-inducible DNA binding upon addition of Ref-1 to immunodepleted extracts. The ability of Ref-1 from heated cells to stimulate AP-1 DNA binding was abolished by chemical oxidation and restored by chemical reduction. These results indicate that heat shock activates c-Fos/c-Jun gene expression and AP-1 DNA binding and suggests that redox-sensitive signal transduction pathways involving Ref-1 may mediate heat-induced alterations in AP-1 activation. | lld:pubmed |
| pubmed-article:10358044 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10358044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10358044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10358044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10358044 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10358044 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10358044 | pubmed:author | pubmed-author:LofgrenSS | lld:pubmed |
| pubmed-article:10358044 | pubmed:author | pubmed-author:LEVYJ PJP | lld:pubmed |
| pubmed-article:10358044 | pubmed:author | pubmed-author:DiamondD ADA | lld:pubmed |
| pubmed-article:10358044 | pubmed:author | pubmed-author:GoswamiP CPC | lld:pubmed |
| pubmed-article:10358044 | pubmed:author | pubmed-author:GiusDD | lld:pubmed |
| pubmed-article:10358044 | pubmed:author | pubmed-author:SpitzD RDR | lld:pubmed |
| pubmed-article:10358044 | pubmed:author | pubmed-author:ParsianAA | lld:pubmed |
| pubmed-article:10358044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10358044 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:10358044 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10358044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10358044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10358044 | pubmed:pagination | 16959-64 | lld:pubmed |
| pubmed-article:10358044 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:meshHeading | pubmed-meshheading:10358044... | lld:pubmed |
| pubmed-article:10358044 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10358044 | pubmed:articleTitle | Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat shock. | lld:pubmed |
| pubmed-article:10358044 | pubmed:affiliation | Section of Cancer Biology, Radiation Oncology Center, Mallinckrodt Institute of Radiology, St. Louis, Missouri 63108, USA. | lld:pubmed |
| pubmed-article:10358044 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10358044 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358044 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10358044 | lld:pubmed |
