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pubmed-article:10344217pubmed:abstractTextTwo genes responsible for hereditary breast cancer (BRCA1 and BRCA2) have been identified, and predisposing mutations identified. Several studies have provided evidence that germline mutations in BRCA1 and BRCA2 confer an increased risk of prostate cancer. Based on these findings, one might expect to find an increased frequency of mutations in these genes in family clusters of prostate cancer. The Ashkenazi Jewish population is unique in that it has an approximate 2% incidence of specific founder BRCA1 and BRCA2 mutations (i.e., 185delAG and 5382insC in BRCA1, and 6174delT in BRCA2).lld:pubmed
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pubmed-article:10344217pubmed:articleTitleNo evidence for a role of BRCA1 or BRCA2 mutations in Ashkenazi Jewish families with hereditary prostate cancer.lld:pubmed
pubmed-article:10344217pubmed:affiliationJames Buchanan Brady Urologic Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.lld:pubmed
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